Day 10 - HemOnc3 Flashcards Preview

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Flashcards in Day 10 - HemOnc3 Deck (30):
1

Leukemia: most common neoplasm in children

ALL

2

Leukemia: most common neoplasm in adults, avg age of onset 50 yo

CLL

3

Leukemia: Philadelphia chromosome almost always seen

CML

4

Leukemia: Smudge cells on smear

CLL

5

Leukemia: Peripheral blasts, PAS+, TdT+

ALL

6

Leukemia: Peripheral blasts, PAS-, Myeloperoxidase+, Auer rods

AML

7

Leukemia: Pancytopenia in Down syndrome pt

ALL

8

Med assoc w/ remission in 95% of CML pts

Imatinib

9

21 yo p/w recent wt loss, pruritus, night sweats; PE - hepatosplenomegaly, nontender cervical LAD

Hodgkin lymphoma

10

Hematologic neoplasm: Assoc EBV

Burkitt Lymphoma

11

Hematologic neoplasm: Reed-Sternberg cells, cervical LAD, night sweats

Hodgkin lymphoma

12

Hematologic neoplasm: Bence Jones proteins, osteolytic lesions, hypercalcemia

Multiple myeloma

13

Hematologic neoplasm: t(14;18)

Follicular lymphoma

14

Hematologic neoplasm: Most common lymphoma in US

Diffuse large b cell

15

Hematologic neoplasm: t(8;14)

Burkitt lymphoma

16

Hematologic neoplasm: t(9;22)

CML (bcr-abl = Philadelphia chromosome); Also 15% adult ALL

17

Hematologic neoplasm: most common form of Hodgkin lymphoma

Nodular sclerosis

18

Hematologic neoplasm: Starry sky appearance

Due to phagocytosis of apoptotic tumor cells; Burkitt lymphoma

19

Hematologic neoplasm: High Hb & Hct, pruritus (especially after hot shower/bath), burning pain in hands/feet

PCV

20

Hematologic neoplasm: blood smear shows hair like projections, splenomegaly

Hairy B cell leukemia

21

Anti-retrovirals: lactic acidosis

NRTIs

22

Anti-retrovirals: GI intolerance

Protease inhibitors

23

Anti-retrovirals: Pancreatitis, Peripheral neuropathy

Zalcitabine, Stavudine, Didanosine (i.e., certain NRTIs); Ritonavir (protease inhibitor) also causes only pancreatitis

24

Anti-retrovirals: Megaloblastic anemia

Zidovudine (i.e., a NRTI)

25

Anti-retrovirals: Rash

NNRTIs

26

Anti-retrovirals: Hyperglycemia, DM, Lipid abnormalities

Indinavir, Sequinavir, Amprenavir (i.e., certain Protease inhibitors)

27

Anti-retrovirals: Bone marrow suppression

Zidovudine (i.e., a NRTI); recall: also causes megaloblastic anemia

28

Anti-retrovirals: Given to pregnant women w/ HIV

Regardless of HAART therapy, can use Zidovudine(i.e., a NRTI) during labor

29

Anti-retrovirals: Recommended for occupational HIV exposure

Zidovudine + Lamivudine (i.e., certain NRTIs)

30

Antibx ppx in HIV pts: when, with what, & for what organisms

CD4

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