demylinating and dysmyelinating diseases Flashcards Preview

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Flashcards in demylinating and dysmyelinating diseases Deck (10):

What are the CSF findings for MS? What are findings for MS on MRI?

CSF findings: increased protein. oligoclonal bands are diagnostic. MRI findings: periventricular plaques (Dawson's fingers) of oligo loss and reactive gliosis


What are some treatments for MS?

beta-interferon, immunosuppression, nataluzimab


How do you treat for neurogenic bladder, pain, and spasticity in MS?

bladder: catheterization, muscarinic antagonists
pain: opioids
spasticity: baclofen, GABA receptor agonist


What is the classic Charcot triad of MS?

scaning speech, intention tremor (also incontinence and internuclear opthalmoplagia), nystagmus


What is acute inflammatory demylinating polyradiculopathy?

most common variant of Guillan-Barre.


What is the underlying problem in Guillan Barre? What cells are affected and in what pattern?

autoimmune condition that destroy Schwann cells. this causes inflammation and demyelination of peripheral nerves and motor fibers, causing a symmetrical ascending muscle weakness and paralysis; half of cases also reach facial paralysis


What are some severe effects of Guillan Barre?

autonomics: cardiac irregularities, hypertension, hypotension. respiratory factors


CSF findings; other findings in Guillan Barre

incr. CSF protein w/ normal cell count. increased protein can cause papilledema


With what infections is Guillan Barre associated?

campylobacter jejuni and CMV. causes autoimmune attack from molecular mimacry


treatment of GBS?

resp support. plasmaphoresis/IV immune globulins

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