Flashcards in thyroid II Deck (10):
hypothyroidism in neonates and infants
causes mental retardation, short stature with skeletal abnormalities, coarse facial features, enlarged tongue, umbilical hernia
causes of cretinsim
maternal hypothyroidism in early pregnancy
dyshomonogenetic goiter: most common enzyme deficiency is thyroid peroxidase
What is myxedema
hypothyroidism in older kid or adult
dough-like edema (increased glycosaminoglycans)
deepened voice and enlarged tongue
decr. basal metolic rate and decr. sympathetic activity
weight gain, normal appetite, slowed mental activity, muscle weakness, cold intolerance, bradycardia w/ decr. output, oligomenorrhea, hypercholesterolemia, constipation
causes of myxedema
iodine deficiency, hashimoto thyroidits, lithium, surgical removal or radio ablation
associated with HLA-DR5 and an increased risk of non-Hodgkin lymphoma (esp. marginal zone lymphoma)
autoimmune destruction of thyroid. typically, it involves anti-thyroid peroxidase antithryoglobulin antibodies, antimicrosomal antibodies. Dr. Sattar says that these do not mediate the disease.
clinical features of hashimoto's
initially presents with hyperthyroid, but then they get hypothyroidism (during destruction, hormone leaks out, but as they destroy the tissue, they eventually get hypothyroid).
T4 down, TSH up.
antithyroglobulin and antimicrosomal abs present- signs of thyroid damage
thyroid will be moderately enlarged and NON-TENDER
histo of hashimotos
chronic inflammation with formation of germinal centers (incr. risk of marginal zone lymphoma)
Hurthle cell change: pink cells in the thyroid.
diseases associated w/ hashimotos' thyroidits
incr risk of B cell lymphoma
subacute granulomatous thyroiditis
after a viral infection
granulomatous inflammation with transient hyperthyroidism
presents as a TENDER thyroid, incr. ESR, jaw pain.
does NOT progress to hypothyroidism