Drug Absorption #2 Flashcards Preview

Pharmaceutics Spring 2016 > Drug Absorption #2 > Flashcards

Flashcards in Drug Absorption #2 Deck (94)
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61

Volume:
____ volume of liquid results in more RAPID emptying

increased; liquids in general empty very fast. they can empty even when there is food in the stomach (takes about 12-15 minutes)

62

Osmolality:
_____ contents empty FASTER than _____ liquids

iso-osmotic; hyper-osmotic

63

T/F There are receptors in the duodenum that detect increases in the osmotic pressure that use feedback mechanism

TRUE

64

_____ increases osmotic pressure

eating/food

65

Emotional state:
_______: increases gastric emptying
_______: decreases gastric emptying

aggression- increase
stress, anxiety- decrease

66

Exercise:
________: have no effect or slight increase in gastric emptying
_________: decrease gastric empyting

moderate intensity; vigorous

67

Posture:
If you are on your ____ side: increase gastric emptying
If you are on your _____ side: decrease gastric emptying

right;left

68

T/F Gastric emptying is FASTER in older people

FALSE: SLOWER

69

T/F Females have slower gastric emptying then males

TRUE

70

What disease states INCREASE gastric emptying? (3)

-hyperthyroidism
-duodenal ulcers
-cholecystitis (inflammation of the gallbladder)

71

Gastritis, GERD, Gastric Carcinoma, Pyloric stenosis, Gastric Ulcers, Diabetic Gastroparesis, Hypothyroidism, Migraine, Pregnancy_______ gastric emptying

decrease

72

What drugs DECREASE gastric emptying? (4)

-narcotic analgesic
-isoniazid--> used to treat TB
-antacids
-tricyclic antidepressants

73

What drugs INCREASE gastric emptying? (2)

-metoclopramide
-erythromycin

74

T/F Food has a great impact on gastric emptying

TRUE: general you would want a patient to take solid dosage form on an empty stomach with a full glass of water

75

Why do we want to get the drug out of the stomach ASAP?

because it is not being absorbed in the stomach and it needs to get in the intestine

76

What is considered an empty stomach with food?

-30 minutes before a meal
-2 hours after a meal

77

Why do some drugs need to be taken with food? (2)

-if drug is irritating
-food increase absorption of some drugs

78

T/F You CAN NOT decrease saturation if given with food

FALSE: you can

79

How could food affect absorption of a drug? (3)

-emptying
-change in pH
-interact with drug

80

Food ____ gastric emptying

slows

81

Food changing the pH could do what?

-increase/decrease absorption
-increase/decrease degradation

82

When the drug Nitrofurantoin was given with food, more excretion (unchanged drug) occurred. Why?

When you give with food emptying is SLOWED making the drug stay in the stomach longer which allows more of the drug to dissolve in the stomach before it is emptied into the intestine

83

T/F Blood flow is static.

FALSE: there is first blood flow through the membrane then the drug is being carried away by the blood

84

rate limiting step

slowest step in the overall process that controls how fast the process will proceed

85

perfusion rate limited (2)

-blood flow step is the slowest step (#2)
-drug freely passes through the membrane with little resistance
ex. water and ethanol

86

diffusion or permeability rate limited

-difficult to cross the membrane, slowly crosses the membrane
ex.ribitol (large polar molecule)

87

When a drug is administered through the muscle (IM), then it only has to cross.....

the blood capillaries

88

Capillary walls are very ______ compared to the GI tract. What type of rate limited is this?

permeable
-molecules with HIGH molar weights easily cross the capillary wall
-perfusion rate limited

89

Would you expect gentamicin, a large polar water soluble molecule to be absorbed well?

NO, because it is big and its polar but if administered into muscle tissue it is readily absorbed

90

The vascularity in the SQ tissue is less than that of muscle tissue, what would you expect to be the effect on absorption?

SQ would have a slower rate of absorption because of less blood flow