Drug Absorption #2 Flashcards Preview

Pharmaceutics Spring 2016 > Drug Absorption #2 > Flashcards

Flashcards in Drug Absorption #2 Deck (94)
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91

SQ administration: What would be the expected effect on the absorption rate following SQ administration in the following situation?

Application of heat or massage the site of administration

INCREASE because blood flow is increasing

92

o SQ administration: What would be the expected effect on the absorption rate following SQ administration in the following situation?

Co-administration of a vasodilator or hyaluronidase (destroy connective tissue)

INCREASE, vasodilator because blood flow is increasing

hyaluronidase will cause the drug to spread out (increasing the SA)

93

o SQ administration: What would be the expected effect on the absorption rate following SQ administration in the following situation?

Co administration of epinephrine that produces vasoconstriction

DECREASE

94

Feedback mechanism in the duodenum (3)

-receptors located in the duodenum, but control emptying in the stomach
-an increase hydronium ions cause SLOW rate of emptying
-osmotic pressure is related to colligative properties