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Dermatology - Clinical Medicine IV > Drug Eruptions > Flashcards

Flashcards in Drug Eruptions Deck (27)
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1

What is ACDR?

adverse cutaneous drug reactions

2

What is ACDR most common at?

skin

3

What is the etiology of ACDR?

immunologic, nonimmunologic, idiosyncratic

4

Who is at high risk of ACDR?

women, elderly, immunocompromised, number of drugs

5

What are common drugs that you can have reaction to?

Penicillins
Aminopenicillins
Sulfonamides
Cephalosporins
Packed RBCs
NSAIDS
Tetracyclines
Fluoroquinolones
Anticonvulsants
Allopurinol

6

What is the most common drug reaction?

exanthematous drug reactions

7

When do you get a EDR?

4-14 days after starting meds

8

What can cause EDR?

any drug, pcn, carbamazepine, allopurinol

9

Does EDR have systemic involvement?

its low

10

What is the clinical presenation of EDR?

pruritis, low grade fever
erythematous macules/papules = confluent, sheet like
symmetrical trunk and extremities
no mucosal involvement
worse before it gets better

11

What is the treatment for EDR?

supportive, oral antihistamines, steroids (Oral vs IV vs Topical)

12

What is AGEP?

acute generalized exanthematous pustulosis

13

How many cases of AGEP are there a year?

1-5 cases/million

14

When is the onset of AGEP?

1-3 weeks after drug administration

15

What is AGEP associated with?

fever, leukocytosis

16

How does AGEP present?

diffuse, edematous erythema starts in folds and face

17

How does fixed drug reaction present?

solitary erythematous patch or plaque +/- pruritic painful burning

18

When is the onset of fixed drug reactions?

30 min 8 hrs after drug ingestation

19

How do you treat fixed drug reaction?

stop the drug, +/- steroids, ABX

20

What is DRESS?

drug reaction with eosinophilia and systemic syndrome

21

What is the clinical presentation of DRESS?

fever, malaise, facial edema, affects liver, heart, lungs, joints, muscules

22

What is the onset of DRESS?

2-6 wks after drug ingestion
antielipetics and sulfonamides

23

What do the lesions look like in DRESS?

morbiliform eruption to exfoliative dermatitis
face, upper trunk, extremities

24

What is the treatment of DRESS?

glucocorticoids

25

When does warfarin induced cutaneous necorsis occur?

3-5 days after initiation

26

What are the lesions like in warfarin necrosis?

petechiae to ecchymosis to hemoorrhagic infarcts to necrosis
areas high in subq fat

27

What are common medications for warfarin necrosis?

heparin, interferon alpha