Flashcards in Drug Eruptions Deck (27)
What is ACDR?
adverse cutaneous drug reactions
What is ACDR most common at?
What is the etiology of ACDR?
immunologic, nonimmunologic, idiosyncratic
Who is at high risk of ACDR?
women, elderly, immunocompromised, number of drugs
What are common drugs that you can have reaction to?
What is the most common drug reaction?
exanthematous drug reactions
When do you get a EDR?
4-14 days after starting meds
What can cause EDR?
any drug, pcn, carbamazepine, allopurinol
Does EDR have systemic involvement?
What is the clinical presenation of EDR?
pruritis, low grade fever
erythematous macules/papules = confluent, sheet like
symmetrical trunk and extremities
no mucosal involvement
worse before it gets better
What is the treatment for EDR?
supportive, oral antihistamines, steroids (Oral vs IV vs Topical)
What is AGEP?
acute generalized exanthematous pustulosis
How many cases of AGEP are there a year?
When is the onset of AGEP?
1-3 weeks after drug administration
What is AGEP associated with?
How does AGEP present?
diffuse, edematous erythema starts in folds and face
How does fixed drug reaction present?
solitary erythematous patch or plaque +/- pruritic painful burning
When is the onset of fixed drug reactions?
30 min 8 hrs after drug ingestation
How do you treat fixed drug reaction?
stop the drug, +/- steroids, ABX
What is DRESS?
drug reaction with eosinophilia and systemic syndrome
What is the clinical presentation of DRESS?
fever, malaise, facial edema, affects liver, heart, lungs, joints, muscules
What is the onset of DRESS?
2-6 wks after drug ingestion
antielipetics and sulfonamides
What do the lesions look like in DRESS?
morbiliform eruption to exfoliative dermatitis
face, upper trunk, extremities
What is the treatment of DRESS?
When does warfarin induced cutaneous necorsis occur?
3-5 days after initiation
What are the lesions like in warfarin necrosis?
petechiae to ecchymosis to hemoorrhagic infarcts to necrosis
areas high in subq fat