Lichenifcation & Acantholysis Flashcards Preview

Dermatology - Clinical Medicine IV > Lichenifcation & Acantholysis > Flashcards

Flashcards in Lichenifcation & Acantholysis Deck (49)
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1

What is tiny perifollicular papules around hair follicles?

keratosis pilaris

2

What causes keratosis pilaris?

keratization causing plugging hair follicular

3

Where do you get keratosis pilaris?

upper thighs, lateral upper arms and cheeks

4

What is the treatment of keratosis pilaris?

moisturizers with ingredients like lactic acid, urea, salicyclic acid (Cerave SA, amlactin)

5

What type of condiation is ichthyosis vulgaris?

Autosomal dominant

6

Fine, adherent scale on extremities and trunk with sparing of flexures, larger scale on lower legs, hyperlinear palms and soles

Ichthyosis Vulgaris

7

What is the pathology of ichthyosis vulgaris?

absent stratum granulosum in some people, decreased or absent profilaggrin, also possible increased adherence of stratum corneum

8

What do pt have ichthyosis vulgaris with (secondary)?

malnutrition, infectious disease, sarcoidosis and other paraneoplastic disorders

9

How do you treat ichthyosis vulgaris?

reduction of scales as in KP

10

the patient has an itch in a particular location and begins to itch – the itching causes a cascade of itching/ scratching in a cycle which leads to thickening of the skin

Lichen Simplex Chronicus

11

When do lichen simplex chronicus pts complain of symptoms?

at rest, not when busy

12

What are the histologic findings for LSC?

epidermal thickening, hyperkeratosis, acanthosis, spongiosis. Papillary dermal fibrosis with vertical streaking of collagen bundles

13

What is the treatment for LSC?

topical steroid, itch prevention, oral snti-puritics including doxepin, phototherapy, psych referral

14

Darkening and thickening of the skin – marker of underlying disease

ACANTHOSIS NIGRICANS

15

Where does acanthosis nigricans present?

skin folds - axillae, groin, back of neck

16

What are the 7 types of acanthosis nigricans?

obesity related, syndromic (Cushings, PCOS), benign(over dorsal hands and feet in AA), drug induced (nicotinic acid, insulin, systemic steroids, hormonal tx), hereditary (autosomal dominant), malignant (stomach CA in 90%), mixed

17

When is acanthosis nigricans itchy?

malignancy

18

What is threatment for acanthosis nigricans?

topical retinoids for cosmetic apperance, creams with exfoliating properties

19

Chronic inflammatory skin condition that is a T cell mediated auto immune disease

lichen planus/ lichen planopilaris

20

Where does lichen planus occur?

nails, hair follicles, skin, oral mucosa, vaginal mucosa, penis

21

What can cause lichen planus/lichen planopilaris?

stress, genetic predisposition, skin trauma (koebnerization), herpes zoster, hepatitis (self antigen modification on surface of basal keratinocytes), meds such as quinidine, hydrxychloroquine, captopril

22

What is the skin findings for lichen planus?

usually symmetrical, scaly papules and plaques, purplish to pink, flat topped, mildly pruritic , may be linea

23

What do you see orally in lichen planus?

Wickham Striae

24

What do you see on the scalp with lichen planus?

telangectasia, erythemia, scarring

25

What is the dx for lichen planus?

get hepatitis hx
biopsy = positive DIF (IG at base of epidermis)

26

What is the treatment for lichen planus?

spontaneous resolution, topical steroids, calcineurin inhibitors

27

Transient acantholytic dermatosis

Grover's disease

28

Who gets grover's disease?

men over 50

29

What can grover's disease be related to?

sweat or heat

30

Where do you get grover's disease?

back and chest