Flashcards in Steven-Johnson's Syndrome Deck (17)
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1
What are characteristics of SJS?
Several life threatening reactions
Extensive necrosis
Epidermis detachment
2
What does SJS start with?
macular and target lesions --> epidermal detachment
3
Where does SJS affect?
skin and mucous (oral, nasal, eyes, vagina, urethra, GI and LRT)
4
How do you differentiate SJS from TEN?
Epidermal Detachment- % BSA
SJS: 30%
5
What are the two presentations in toxic epidermal necrolysis?
Macular/Target lesions (50% of cases)
Diffuse erythema to immediate necrosis
6
What are the most common drugs for SJS?
NSAIDs
Antibiotics- sulfonamides, PCN
Anticonvulsants
Allopurinol
7
What are the most common infectious causes?
Mycoplasma pneumoniae, viral infections, immunizations
8
What is teh epi of EJE/TEN?
more common >40 yo
M=F
TEN less common than SJS
9
When is the onset of SJS?
1-3 wks
10
What is the prodrom of SJS?
fever, malaise, arthralgias
11
What are the clinical manifestations of SJS?
Skin tenderness/burning
Conjunctival burning
Painful/tender mouth lesions
12
What is the work up for SJS?
None needed
13
What is the treatment of SJS/TEN?
Remove offending agent
Fluid resuscitation
ICU/Burn Unit
+/- systemic glucocorticoids
? IV immunoglobins
Skin Care
Ocular manifestations
14
How long does it take for lesions to heal?
1-2 weeks
15
What does SCORTEN score?
severity of illness, mortality rate
16
What is the mortality of SJS/TEN?
30% skin sloughing- 25-35%
17
