Flashcards in Steven-Johnson's Syndrome Deck (17)
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1
Q
What are characteristics of SJS?
A
Several life threatening reactions
Extensive necrosis
Epidermis detachment
Extensive necrosis
Epidermis detachment
2
Q
What does SJS start with?
A
macular and target lesions --> epidermal detachment
3
Q
Where does SJS affect?
A
skin and mucous (oral, nasal, eyes, vagina, urethra, GI and LRT)
4
Q
How do you differentiate SJS from TEN?
A
Epidermal Detachment- % BSA
SJS: 30%
SJS: 30%
5
Q
What are the two presentations in toxic epidermal necrolysis?
A
Macular/Target lesions (50% of cases)
Diffuse erythema to immediate necrosis
Diffuse erythema to immediate necrosis
6
Q
What are the most common drugs for SJS?
A
NSAIDs
Antibiotics- sulfonamides, PCN
Anticonvulsants
Allopurinol
Antibiotics- sulfonamides, PCN
Anticonvulsants
Allopurinol
7
Q
What are the most common infectious causes?
A
Mycoplasma pneumoniae, viral infections, immunizations
8
Q
What is teh epi of EJE/TEN?
A
more common >40 yo
M=F
TEN less common than SJS
M=F
TEN less common than SJS
9
Q
When is the onset of SJS?
A
1-3 wks
10
Q
What is the prodrom of SJS?
A
fever, malaise, arthralgias
11
Q
What are the clinical manifestations of SJS?
A
Skin tenderness/burning
Conjunctival burning
Painful/tender mouth lesions
Conjunctival burning
Painful/tender mouth lesions
12
Q
What is the work up for SJS?
A
None needed
13
Q
What is the treatment of SJS/TEN?
A
Remove offending agent
Fluid resuscitation
ICU/Burn Unit
+/- systemic glucocorticoids
? IV immunoglobins
Skin Care
Ocular manifestations
Fluid resuscitation
ICU/Burn Unit
+/- systemic glucocorticoids
? IV immunoglobins
Skin Care
Ocular manifestations
14
Q
How long does it take for lesions to heal?
A
1-2 weeks
15
Q
What does SCORTEN score?
A
severity of illness, mortality rate
16
Q
What is the mortality of SJS/TEN?
A
30% skin sloughing- 25-35%
17
Q
SJS vs TEN
A
Epidermal Detachment- % BSA
SJS: 30%
SJS: 30%
