Steven-Johnson's Syndrome Flashcards Preview

Dermatology - Clinical Medicine IV > Steven-Johnson's Syndrome > Flashcards

Flashcards in Steven-Johnson's Syndrome Deck (17)
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1

What are characteristics of SJS?

Several life threatening reactions
Extensive necrosis
Epidermis detachment

2

What does SJS start with?

macular and target lesions --> epidermal detachment

3

Where does SJS affect?

skin and mucous (oral, nasal, eyes, vagina, urethra, GI and LRT)

4

How do you differentiate SJS from TEN?

Epidermal Detachment- % BSA
SJS: 30%

5

What are the two presentations in toxic epidermal necrolysis?

Macular/Target lesions (50% of cases)
Diffuse erythema to immediate necrosis

6

What are the most common drugs for SJS?

NSAIDs
Antibiotics- sulfonamides, PCN
Anticonvulsants
Allopurinol

7

What are the most common infectious causes?

Mycoplasma pneumoniae, viral infections, immunizations

8

What is teh epi of EJE/TEN?

more common >40 yo
M=F
TEN less common than SJS

9

When is the onset of SJS?

1-3 wks

10

What is the prodrom of SJS?

fever, malaise, arthralgias

11

What are the clinical manifestations of SJS?

Skin tenderness/burning
Conjunctival burning
Painful/tender mouth lesions

12

What is the work up for SJS?

None needed

13

What is the treatment of SJS/TEN?

Remove offending agent
Fluid resuscitation
ICU/Burn Unit
+/- systemic glucocorticoids
? IV immunoglobins
Skin Care
Ocular manifestations

14

How long does it take for lesions to heal?

1-2 weeks

15

What does SCORTEN score?

severity of illness, mortality rate

16

What is the mortality of SJS/TEN?

30% skin sloughing- 25-35%

17

SJS vs TEN

Epidermal Detachment- % BSA
SJS: 30%