Flashcards in Steven-Johnson's Syndrome Deck (17)
What are characteristics of SJS?
Several life threatening reactions
What does SJS start with?
macular and target lesions --> epidermal detachment
Where does SJS affect?
skin and mucous (oral, nasal, eyes, vagina, urethra, GI and LRT)
How do you differentiate SJS from TEN?
Epidermal Detachment- % BSA
What are the two presentations in toxic epidermal necrolysis?
Macular/Target lesions (50% of cases)
Diffuse erythema to immediate necrosis
What are the most common drugs for SJS?
Antibiotics- sulfonamides, PCN
What are the most common infectious causes?
Mycoplasma pneumoniae, viral infections, immunizations
What is teh epi of EJE/TEN?
more common >40 yo
TEN less common than SJS
When is the onset of SJS?
What is the prodrom of SJS?
fever, malaise, arthralgias
What are the clinical manifestations of SJS?
Painful/tender mouth lesions
What is the work up for SJS?
What is the treatment of SJS/TEN?
Remove offending agent
+/- systemic glucocorticoids
? IV immunoglobins
How long does it take for lesions to heal?
What does SCORTEN score?
severity of illness, mortality rate
What is the mortality of SJS/TEN?
30% skin sloughing- 25-35%