Flashcards in Topical Antibacterials Deck (22)
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1
What are the uses for topical antibacterials?
Prevent infection in fresh wounds
Early treatment of superficial infections
Reduce colonization of nares
Acne
2
What is bactracin and gramicidin used for?
Gram +. anaerobic coci, nesseriae, tetanus bacilli, diptheria bacilli
3
What are the bactracin products?
bacitracin alone or in combo with neomycin polymyxin B
OTC
4
What are common pathogens in skin infections?
GAS,. S. aureus
5
What is bacitracin opthalmic ointment?
RX only
6
What is gramicidin?
rx combo with neomycin, polymyxin B for opthalmic use
7
What is mupirocin?
bactroban, centany
8
What is the spectrum of mupirocin?
gram + including MRSA
9
What is the patho of mupirocin?
Binds bacterial isoleucyl transfer-RNA synthetase preventing protein synthesis
10
How do you get mupirocin?
Rx only
Cream, ointment, nasal ointment
11
What are the uses for mupirocin?
Intranasal – eradication of MRSA; general prophylaxis in patients with recurrent nasal tract infections BID x 5 days
Cream – traumatic skin lesions containing S. aureus, S. pyogenes TID x 10 days
Ointment – impetigo due to S. aureus, S. pyogenes TID x 3-5 days
12
What is retapamulin?
altabax
13
What is the spectrum for retapamulin?
group A β-hemolytic strep and S. aureus (NOT MRSA)
14
What does retapamulin do?
binds ribosomal 50S subunit
15
What does mupirocin treat that is key?
MRSA
16
What is the use for retapamulin?
impetigo BID x 5 days
17
What does polymyxin B sulfate do?
increase permeability of cell wall
18
What is the spectrum of polymyxin B sulfate?
Gram -
proteus, serratia, gram + are resistant
19
What is the use of polymyxin B sulfate?
Injection: serious infections resistant to less toxic drugs; drug of choice for P. aeruginosa infection of blood, urinary tract, meninges when susceptible
Nephrotoxic, neurotoxic
Topical in combo with bacitracin +/- neomycin for first aid
20
What does neomycin and gentamicin cover?
gram -
21
Gent is good for?
pseudomonas but is resistant
22
