Flashcards in Endocrine Path Quiz 3- pat 2 Deck (28):
the condition that most commonly causes hypothyroid in US?
endemic goiter is a term to describe
an enlarged thyroid due to inadequate intake of iodine (not a problem in most developed countries)
what is the term for accidental ingestion of excess quantities of thyroid hormone?
Hashimoto's may present with
enlargement of the thyroid due to lymphocytic infiltration and fibrosis
what causes gradual destruction of follicles in the thyroid gland?
antibodies against thyroid peroxidase (anti TPO Ab) and/or thyroglobulin
microscopic appearance of thyroid tissue in Hashimoto's
-can see movement away from single layer of epithelium
-colloid is no longer acellular, with lymphocytic infiltration
A Hürthle cell is associated with? appear how?
- Hashimoto's thyroiditis
- enlarged epithelial cells with abundant eosinophilic granular cytoplasm
what are the antibodies against thyroid peroxidase called?
De Quervain's thyroiditis (a type of subacute thyroiditis) presents with which notable sx?
-painful enlarged thyroid
microscopically de Quervain's disease shows which type of cells?
multi-nucleated giant cells within the colloid
represents the most common cause for an enlarged thyroid gland, and world-wide, it represents the most common disease of the thyroid
Non-toxic multinodular goiter
Microscopic appearance of non-toxic multinodular goiter
-irregularly enlarged follicles
A toxic nodular goiter (TNG) is a thyroid gland that contains autonomously functioning thyroid nodules, resulting in
hyperthyroidism (excess T3/T4)
Toxic nodular goiter
characteristics of goiter:
Dissimilar from which condition:
-Off to one side, elderly
-Grave's is symmetrical, adolescence
microscopic appearance of toxic nodular goiter
-normal looking cells
-an AI disease
-long acting thyroid autoantibodies (LATS-Ab) activate TSH receptors
-stimulate production of T3/T4
most common cause of hyperthyroidism in US
most common cause of hyperthyroidism worldwide?
(rare in US)
microscopic appearance of Grave's disease
-tall columnar thyroid epithelium
-vacuoles in the colloid (scalloping)
-depletion of colloid
most common type of thyroid cancer?
Papillary cancer (least malignant)
most malignant type of thyroid cancer?
Undifferentiated/Anaplastic (least common)
When is papillary carcinoma more malignant (ordinarily very responsive to treatment)?
when diagnosed in elderly
psammoma body seen in
if papillary carcinoma were to METS, would it do so via lymph or blood?
second most common thyroid cancer?
more malignant than papillary carcinoma
microscopic appearance of follicular carcinoma
*can be hard to distinguish from follicular adenoma
which thyroid cancer shows proliferation of parafollicular cells (C cells) which results in excess amounts of?
-calcitonin (detectable in serum)