Flashcards in Endocrine Path Quiz 3- part 5 Deck (13):
Lab Criteria for dx DM
-Confirmed fasting blood glucose > 126 mg/dl
-A non-fasting blood glucose of > 200 mg/dL
-A positive oral glucose intolerance test (OGTT) resulting in a blood glucose > 200 mg/Dl at 2-3 hrs following a glucose bolus
-Hgb A1C > 6.5%
which of the following is a diabetes as the result of an autoimmune disease?
Type 1 DM
which two antibodies should be detectable in Type 1 DM?
-islet cell antibodies
most islet cell antibodies are directed against ________ within pancreatic beta cells
glutamic acid decarboxylate (GAD)
Type ____ leads to beta cells being burnt out due to insulin resistance such that you eventually you no longer produce insulin, or minimal levels, but negligible _____ found
microscopic view of islet of langerhans shows ______ in type 1 DM
common changes seen in islet cells in type 2 DM?
hyalinization with deposition of amyloid
The longer a person has diabetes, the higher his or her chances of developing
The earliest detectable visible change in the course of diabetic nephropathy is
thickening of the capillaries within the glomerulus
multiple peptic ulcers in the stomach and duodenum
An insulinoma is a tumor occurring where?
pancreatic tumor derived from beta cells
Gastrinoma secretes excess gastrin leading to
excess HCl (sx: ulcers in stomach, duodenum and SI and diarrhea)