Endocrine Path Quiz 3- part 5 Flashcards Preview

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Flashcards in Endocrine Path Quiz 3- part 5 Deck (13):
1

Lab Criteria for dx DM

-Confirmed fasting blood glucose > 126 mg/dl
-A non-fasting blood glucose of > 200 mg/dL
-A positive oral glucose intolerance test (OGTT) resulting in a blood glucose > 200 mg/Dl at 2-3 hrs following a glucose bolus
-Hgb A1C > 6.5%

2

which of the following is a diabetes as the result of an autoimmune disease?

Type 1 DM

3

which two antibodies should be detectable in Type 1 DM?

-islet cell antibodies
-anti-insulin antibodies

4

most islet cell antibodies are directed against ________ within pancreatic beta cells

glutamic acid decarboxylate (GAD)

5

Type ____ leads to beta cells being burnt out due to insulin resistance such that you eventually you no longer produce insulin, or minimal levels, but negligible _____ found

2; Abs

6

microscopic view of islet of langerhans shows ______ in type 1 DM

leukocytic infiltration

7

common changes seen in islet cells in type 2 DM?

hyalinization with deposition of amyloid

8

The longer a person has diabetes, the higher his or her chances of developing

diabetic retinopathy

9

The earliest detectable visible change in the course of diabetic nephropathy is

thickening of the capillaries within the glomerulus

10

Zollinger–Ellison syndrome

multiple peptic ulcers in the stomach and duodenum

11

An insulinoma is a tumor occurring where?

pancreatic tumor derived from beta cells

12

Gastrinoma secretes excess gastrin leading to

excess HCl (sx: ulcers in stomach, duodenum and SI and diarrhea)

13

what turns out to be the cause of Zollinger-Ellison syndrome?

Gastrinomas