Muscle Path Quiz 4 Flashcards Preview

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Flashcards in Muscle Path Quiz 4 Deck (21):
1

microscopic view of muscle atrophy (disuse atrophy)

diminished uptake of stain
diminished muscle mass
adipose tissue increases

2

the most common and one of the most serious forms of muscular dystrophy

Duchenne's

3

Duchenne's is also called what? why is it called this?

pseudohypertrophy
because it looks like they have muscular calves, but muscle gets replaced by fat

4

Duchenne's is due to a defective gene on the X chromosome that leads to an inability to produce which protein?

dystrophin

5

inability to produce dystrophin in Duchenne's leads to what?

excess calcium enters cell causing cell death

6

An _______, Duchenne’s occurs almost exclusively _________

X-linked recessive disease; in boys

7

Myasthenia gravis is caused by

Abs that block Ach receptors
Post-synaptic

8

muscle weakness that worsens during periods of activity and improves after periods of rest is the hallmark for which disease?

Myasthenia gravis

9

thymoma is a rare tumor of the thymus gland associated with which condition?

Myasthenia gravis

10

which lab is routinely done in myasthenia gravis?

serum anti-acetylcholine receptor antibodies

11

Lambert-Eaton syndrome is associated with which cancer?

small cell lung cancer

12

Lambert-Eaton syndrome is caused by

Abs that block calcium channels
pre-synaptic

13

in Lambert-Eaton syndrome, the pre-synaptic block of calcium channels has what effect?

prevents release of Ach

14

Lymphocytes invade a myofiber in this skeletal muscle biopsy from a patient diagnosed with

Dermatomyositis

15

In dermatomyositis, a characteristic __________ rash is usu present

periorbital heliotrope

16

Another type of rash associated with dermatomyositis is termed_________
shows up on dorsum of hands

Gotrron's sign

17

what's a poor prognostic sign for polymyositis?

dysphagia

18

microscopic view of polymyositis reveals

Muscles fibers appear pale & enlarged
cellular invasion by macrophages

19

The biopsy appearance of inclusion body myositis is characterized by

focal areas of WBCs that invade muscle cell
vacuoles
amyloid-related protein
inclusions

20

Rhabdomyomas are benign tumors of what type of muscle?
where are they found

-striated muscle
-head and neck

21

the most common soft tissue tumor in children

Rhabdomyosarcoma