Endocrine Path Quiz 3- part 4 Flashcards Preview

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Flashcards in Endocrine Path Quiz 3- part 4 Deck (20):
1

adrenal cortex secretes which 3 hormones?

glucocorticoids (cortisol)
mineralocorticoids (aldosterone)
sex hormones (DHEA)

2

overproduction of the hormones produces by the adrenal cortex is most likely due to what?

adenoma

3

major hormone produced by adrenal medulla?

epinephrine (aka adrenalin)
also produce nor-epinephrine and dopamine

4

aldosterone is under control by which system?

renin-angiotensin system (rather than H-P axis)

5

primary hyperaldosteronism aka ________
usu due to ________

Conn's syndrome
adenoma

6

often the only clinic sign of Conn's is

hypertension (due to hypernatremia)

7

important lab findings of Conn's

High serum aldosterone
Low serum potassium and high serum sodium
Decreased plasma renin (suppressed by elevated aldosterone level)

8

what's causing the excess cortisol production seen in Cushing's?

pituitary tumors secreting excess ACTH
happening at level of brain NOT adrenals!!!

9

what is a manifestation of Cushing's?

hyperglycemia

10

what's causing the low cortisol levels seen in Addison's disease?
primary?
secondary?

primary = adrenal gland itself damaged.
secondary= insufficient ACTH results in atrophy of adrenal cortex

11

The most common cause of primary Addison’s disease is

autoimmune destruction of the adrenal cortex

12

what clinical presentation is seen with primary Addison's?
why?

-Hyperpigmentation
-with increased ACTH production stimulate melanocytes to produce more melanin

13

trauma or adrenal hemorrhage from sepsis is called?

waterhouse-frederickson syndrome

14

how is the condition waterhouse-frederickson syndrome related to Addison's?

disrupts normal function of adrenal gland
considered a secondary cause of Addison's dz

15

how to distinguish primary from secondary Addison's disease?

primary - hyperpigmentation
secondary- skin pallor

16

in 95% of cases of congenital adrenal hyperplasia (CAH), what enzyme is deficient?

21-Hydroxylase

17

which enzyme converts testosterone to estrogen (irreversibly)?

aromatase

18

the most common solid, extra-cranial malignancy in infants and children is?

neuroblastoma

19

where do neuroblastomas arise from?

most often arise from the adrenal glands but may be seen anywhere along the sympathetic chain

20

what is the characteristic appearance for neuroblastoma microscopically?

Rosettes