CNS Path Quiz 6 part 1 Flashcards Preview

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Flashcards in CNS Path Quiz 6 part 1 Deck (22):
1

Neurosyphilis is caused by

treponema pallidum

2

There are several types of neurosyphilis. what are they and what are the pertinent features?

Meningovascular syphilis- perivascular inflammation in brain
Paretic syphilis- widespread parenchymal invasion
Tabes dorsalis- ataxia and proprioception *

3

Most common presentation of meningiovascular syphilis is?

a stroke occurring in a young adult

4

Tabes dorsalis is a form of neurosyphilis involving...?

the posterior column

5

Neurosyphilis often results in the formation of meningeal granulomas known as

gummas

6

A gumma results from

a cell-mediated immune response to Treponema

7

which of the following organisms can have the Jarish-Herxhemier rxn?

syphilis (treponema pallidum)

8

Jarisch-Herxheimer reaction occurs

following treatment of syphilis

9

Subacute sclerosing panencephalitis (SSPE) is associated with

rubeola
it occurs 1-20+ yrs after measles

10

Subacute sclerosing panencephalitis would show a normal CSF profile, unless you specifically ordered which test?

Rubeola IgG Antibody

11

microscopic appearance of subacute sclerosing panencephalitis

eosinophilic inclusion bodies

12

most notable polio sx

flaccid paralysis

13

After a period of viremia, the polio virus becomes neurotropic and produces destruction of the

motor neurons in the anterior horn and brainstem

14

the rabies virus travels

via the peripheral nerves from the site of the bite to the brain

15

death from rabies usually occurs within a week due to

cardiac or respiratory failure

16

what is 100% diagnostic for rabies (if present)?

Negri bodies
inclusion bodies within neurons

17

what are frequent sites of attack for rabies virus?

Temporal lobe neurons and cerebellar Purkinje cells

18

the frequency of AIDS dementia complex (ADC) increases as

CD4+ cell counts decrease

19

In AIDS dementia, macrophages are infected and wind up in the brain. Macrophages release substance that can be toxic. like what?

quinolinic acid
cytokines
other signal molecules
infected macrophages can shed gp120

20

what is Reye's syndrome?
what causes it?

fatty infiltration of the liver and swelling of the kidneys and brain
caused by treating chicken pox with aspirin

21

two main forms of spongiform encephalopathy?

Kuru
Creutzfeldt-Jakob disease (CJD)

22

there's a causal relationship between which two prion diseases?

bovine spongiform encephalopathy and variant Creutzfeldt-Jakob diseases (vCJD)