Flashcards in CNS Path Quiz 6 part 1 Deck (22):
Neurosyphilis is caused by
There are several types of neurosyphilis. what are they and what are the pertinent features?
Meningovascular syphilis- perivascular inflammation in brain
Paretic syphilis- widespread parenchymal invasion
Tabes dorsalis- ataxia and proprioception *
Most common presentation of meningiovascular syphilis is?
a stroke occurring in a young adult
Tabes dorsalis is a form of neurosyphilis involving...?
the posterior column
Neurosyphilis often results in the formation of meningeal granulomas known as
A gumma results from
a cell-mediated immune response to Treponema
which of the following organisms can have the Jarish-Herxhemier rxn?
syphilis (treponema pallidum)
Jarisch-Herxheimer reaction occurs
following treatment of syphilis
Subacute sclerosing panencephalitis (SSPE) is associated with
it occurs 1-20+ yrs after measles
Subacute sclerosing panencephalitis would show a normal CSF profile, unless you specifically ordered which test?
Rubeola IgG Antibody
microscopic appearance of subacute sclerosing panencephalitis
eosinophilic inclusion bodies
most notable polio sx
After a period of viremia, the polio virus becomes neurotropic and produces destruction of the
motor neurons in the anterior horn and brainstem
the rabies virus travels
via the peripheral nerves from the site of the bite to the brain
death from rabies usually occurs within a week due to
cardiac or respiratory failure
what is 100% diagnostic for rabies (if present)?
inclusion bodies within neurons
what are frequent sites of attack for rabies virus?
Temporal lobe neurons and cerebellar Purkinje cells
the frequency of AIDS dementia complex (ADC) increases as
CD4+ cell counts decrease
In AIDS dementia, macrophages are infected and wind up in the brain. Macrophages release substance that can be toxic. like what?
other signal molecules
infected macrophages can shed gp120
what is Reye's syndrome?
what causes it?
fatty infiltration of the liver and swelling of the kidneys and brain
caused by treating chicken pox with aspirin
two main forms of spongiform encephalopathy?
Creutzfeldt-Jakob disease (CJD)