SKM Path Quiz 4- part 1 Flashcards Preview

Pathology IV > SKM Path Quiz 4- part 1 > Flashcards

Flashcards in SKM Path Quiz 4- part 1 Deck (41):
1

idiopathic avascular osteonecrosis of the epiphysis of the femoral head leading to an interruption of the blood supply of the head of the femur

Legg–Calvé–Perthes syndrome

2

The predominant cause of rickets is?

Vitamin D deficiency
causes softening of the bones

3

what is rickets called that's seen in adults?

Osteomalacia

4

what's responsible for the osteoclast activity seen in osteoporosis?

cytokines
IL-1, IL-6, TNF alpha

5

primary osteoporosis caused by

aging
menopause

6

secondary osteoporosis caused by

malabsorption
medical conditions (RA, endocrine disorders)
medications (steroids, chemotherapy, anticoagulants)
eating disorders
immobilization
vitamin deficiency (Vit D, C, K)

7

exaggerated curvature of the spine that results in a rounded or hunched back

kyphosis

8

a disease characterized by high bone turnover with accelerated osteoclast and osteoblast activity

Paget's disease

9

end result of Paget's disease is

increased calcification
imaging shows whiter areas of bone

10

Labs for Paget's show elevated

alkaline phosphate

11

histological hallmark for Paget's is

mosaic pattern of lamellar bone

12

Paget's disease reveals what when seen via x-ray?

sclerotic bone
areas of lucency
(cotton ball appearance)

13

osteopetrosis characterized by

bones harden and become more dense

14

gas formation in tissue is seen on x-ray for which condition?

osteomyelitis

15

Diagnosis of osteomyelitis is often based on radiologic results showing

a lytic center with a ring of sclerosis.

16

renal osteodystrophy is used to describe

all of the skeletal changes of chronic renal disease

17

Fractures are classified as simple (closed) when

the overlying tissue is intact

18

Fractures are classified as compound (open) when

the fracture site communicates with the skin surface

19

A fracture is displaced when

the ends of the bone at the fracture site are not aligned

20

A fracture is called comminuted when the bone is

splintered or crushed

21

a pathologic fracture is

when the break occurs in bone already altered by a disease process

22

A stress fracture is

a slowly developing fracture that follows a period of increased physical activity in which the bone is subjected to repetitive loads

23

An abnormal bone scan will appear as

increased uptake of the tracer where bone formation is occurring faster than the surrounding bone

24

on x-ray aneurysmal cyst reveals

honey-combed appearance
less symmetry to shape of cyst

25

which type of benign bone neoplasm is often solitary, but when paired with Gardner syndrome multiple lesions are seen?

osteoid osteoma

26

Gross examination of an osteoid osteoma is characterized by

an area of gritty, cherry red tissue, surrounded by dense sclerotic bone

27

the primary malignant tumor of bone is

osteosarcoma

28

third most common malignancy is adolescence?

osteosarcoma

29

osteosarcoma, while ordinarily seen in young adults, is seen more commonly in adults that have which other condition?

Paget's

30

osteosarcoma feels

hard
fixed
non-tender

31

_________ is a chemosensitive tumor specially to high-dose methotrexate

osteosarcoma

32

X-ray findings for osteosarcoma are variable

combination of bone destruction and bone formation
radio lucency and radio opacity
spicules of calcium in soft tissue

33

METS of osteosarcoma is common and characteristic appearance is

skip lesions

34

Early pulmonary metastasis is common with

osteosarcoma

35

microscopically fibrosarcoma appears as

sheets of spindle shaped cells

36

Giant cell tumor (GCT) appears as what on x-ray

non-sclerotic border

37

a bone tumor mostly of adults?

giant cell tumor

38

a bone tumor mostly of children?

ewing sarcoma

39

X-ray of Ewing sarcoma usually shows

a mottled "moth-eaten" destructive lesion

40

malignant disease of plasma cells in bone marrow

multiple myeloma

41

METs bone cancer or Paget's shows what on x-ray?

ivory vertebrae sign