Flashcards in EXAM #1: GI NEOPLASIA Deck (75)
What type of tumor is the most common in the GI tract?
What site is most commonly affected by neoplasia in the GI system?
What are the most common benign tumors of the small bowel?
2) Mesenchymal tumors i.e. GISTs
What are the most common malignant tumors of the small bowel?
What genetic conditions predipose patients to carcinomas of the small bowel?
1) Familial Adenomatous Polyposis (FAP)
2) Gardner's Syndrome
What is an adenoma?
Neoplastic proliferation of glands
Where are adenomas in the small bowel most common?
Amupulla of Vater --this is the union of the pancreatic duct and common bile duct
What are the clinical features of adenomas?
- Seen in middle age
- Cause occult blood loss
- Can precipitate obstruction/ intussusception
Where do most adenocarcinomas occur in the small bowel?
What type of pattern do adenocarcinomas grow in?
Napkin ring i.e. encircling
What is the major non genetic risk factor for adenocarcinomas?
What is a polyp?
Benign mass protruding from the mucosa into the lumen of the gut
Are most polyps malignant or non-malignant?
What are the two types of polyps seen in the colon?
What is a hyperplastic polyp?
Hyperplasia of glands
What is a Hamartomatous polyps?
A polyp formed by disorganized normal tissue (seen mostly in kids; therefore, called a "Juvenile Polyp")
What is an inflammatory polyp?
This is an alternate name for pseudopolyps seen in Ulcerative Colitis
What type of polyp is most common?
Where do most hyperplastic polyps occur?
What are harmatomatous polyps called in kids?
What are harmatomatous polyps called in adults?
What are Peustz-Jegher's polyps?
Hamartomatous polyps seen in Peutz-Jegher's Syndrome
- Polyps seen throughout the GI tract (vs. solitary)
What is Peutz-Jegher's Syndrome?
- Autosomal Dominant disorder
- Characterized by:
1) Mucocutaneous pigmentation around the mouth (freckles around the mouth)
2) Multiple hamartomatous polyps
What gene is mutated in Peutz-Jegher's Syndrome?
What are the hamartomatous polyps of Peutz-Jegher's Syndrome composed of?
1) Connective tissue
2) Smooth muscle
What are patients with Peutz-Jegher's Syndrome at risk for?
What are the four different types of adenomas?
What is the most common type of ademona? What is the association with carcinoma?
****Lowest neoplastic potential b/c of "buffering" of the stalk*****
Which type of adeoma is most associated with carcinoma?