EXAM #2: VIRAL HEPATITIS Flashcards Preview

Gastrointestinal System > EXAM #2: VIRAL HEPATITIS > Flashcards

Flashcards in EXAM #2: VIRAL HEPATITIS Deck (52)
Loading flashcards...
1

Describe the histologic appearance of hepatitis.

- Blue= bad, lymphocytes
- Pink= good

2

What are the complications of hepatitis?

1) Cirrhosis
2) Hepatocellular carcinoma

3

How does cirrhosis appear histologically?

- Fibrosis (blue) with islands of normal liver tissue (pink)
- Regenerative nodules

4

What are the signs and symptoms of hepatitis?

- Majority of patients are asymptomatic
- Some with acute hepatitis have vague flu-like symptoms

5

What is self-limiting hepatitis?

Hepatitis that is self-resolving

6

What is fulminant hepatitis?

Overwhelming liver inflammation that leads to liver failure

7

List the etiologies of hepatitis.

1) Infectious
2) Immune related
3) Chemicals/toxins
4) Medications
5) Ischemia
6) Hereditary
7) Pregnancy
8) Alcohol
9) NAFLD

8

What are the immune related causes of hepatitis?

1) PBC--primary biliary cirrhosis
2) Primary Sclerosing Cholangitis (complication of UC)
3) Autoimmune

9

What are the self-limited causes of viral hepatitis?

HAV and HEV

10

What patient population is autoimmune hepatitis most common in?

Middle aged females

11

What antibodies are positive in autoimmune hepatitis?

1) Antinuclear antibody (ANA)
2) Anti-smooth muscle antibody (ASMA)
3) Anti-LKM

12

How is autoimmune hepatitis treated?

- Steroids
- Immunomodulators--Azathioprine

13

What is the classic histologic finding in autoimmune hepatitis?

Severe inflammation of the portal triads

14

What is Primary Biliary Cirrhosis?

Immune mediated destruction of the BILE CANALICULAE

15

What antibody is associated with PBC?

Anti-mitochondrial antibody (AMA)

16

What are patients with PBC at risk for?

1) Hyperlipidemia
2) Osteoporosis

17

What is the treatment for PBC?

Urso (bile acid supplement)

18

What is PSC?

Immune mediated destruction of the large bile ducts leading to stricture/ obstructive jaundice

19

What disease is PSC strongly associated with?

UC

20

How is PSC treated?

Currently there is no effective therapy

21

What is the most common cause of non-hepatitis virus infection causing hepatitis?

EBV (mononucleosis)

22

What is unique about the liver reaction to Isoniazid (INH)?

- Undetected hepatitis from INH can lead to cirrhosis
- Mandated that INH administration is followed with LFT measuring

23

What four chemicals will cause a dose-dependent liver destruction?

1) Tylenol*
2) Amanita Phalloides (mushroom)
3) White phosphorus
4) Carbon Tetrachloride

24

What type of virus is HAV?

Picornoviridae--ssRNA

25

What is HAV infection associated with?

Traveling is considered classic
- South America
- Africa
- SE Asia
- Greenland*

*****HOWEVER, in the US, DAYCARE is the most common*****

26

How is HAV transmitted? What are the unusual modes of transmission?

Fecal-oral
- Homosexual activity
- IVDA

27

What lab test is associated with symptomatic HAV infection?

ALT elevation is associated with symptomatic HAV

28

What are the worrisome variants of HAV infection?

1) Cholestatic hepatitis
2) Relapsing hepatitis
3) Fulminant hepatitis

29

What type of virus is HBV?

Hepadnaviridae--dsDNA

30

Is HBV enveloped?

Yes