EXAM #2: HEPATITIS C Flashcards Preview

Gastrointestinal System > EXAM #2: HEPATITIS C > Flashcards

Flashcards in EXAM #2: HEPATITIS C Deck (26):
1

What type of virus is HCV?

- Flaviviridae
- ssRNA

2

Is Hepatitis C enveloped?

Yes

3

Where is the highest incidence of HCV worldwide?

Egypt

4

What populations is HCV most prevalent in?

1) IVDA
2) Incarcerated
3) HIV
4) Alcoholics
5) Homeless

5

Why is snorting cocaine a risk factor for HCV infection?

- Nosebleeds are associated with cocaine use
- Breach in the mucosa

6

In what age group is there the highest prevalence of HCV?

Baby-boomer (born before 1964)

7

Are tattoo parlors and blood transfusions still considered risk factors for HCV infection?

No

- HCV education in tattoo parlors has lowered risk
- Screening has lowered risk for transfusion

8

When is there a high risk of sexual transmission of HCV?

Woman with HCV and HIV

*Monogamous HCV alone is considered low risk for sexual transmission*

9

What is unique about HCV and liver enzyme tests?

LTF levels fluctuate

*Patient may have normal ALT and HCV with cirrhosis

10

What percent of patients with HCV will develop HCC per year?

4%

11

What is the worst social behavior associated with HCV infection?

Alcoholism--this is "like throwing gasoline on a fire"

12

What do you need to remember about HCV infection?

This is a SYSTEMIC disease that can have numerous extrahepatic manifestations

13

Who needs to be screened for HCV?

Anyone born between 1940 and 1964

14

How is HCV screened for?

1) HCV antibody screening
2) HCV-RNA confirmation

15

What is the major determinant of HCV therapy/ success with treatment?

Genotype

16

What genotype is most resistant to treatment?

Genotype 1 i.e. what is most prevalent in the US

17

What is the primary goal of HCV therapy?

Eradicate HCV

18

What is the most important secondary goal of HCV therapy?

Reduce HCC incidence

19

What does "sustained viral respose" refer to?

Successful HCV
- Viral load drops
- This is NOT a cure b/c virus will still be detectable

20

What is pegylated interferon?

- Interferon linked to a bulky inert molecule
- Decreases metabolism of interferon

21

What are the adverse effects associated with Interferon?

*Interferon is the same cytokine that kills the flu--it is what causes the sx of flu*

Thus, the side effects resemble the flu

22

What DAAs?

Direct anti-viral agents

23

What is the standard of care of HCV infection now?

Harvoni--Sofosbuvir + Ledipasvir

24

What is the MOA of Harvoni?

Inhibits HCV at 3 locations:

25

What is the single most common reason for liver transplant?

HCV

26

Outline the high points of the HCV timeline.

1985= nothing known
1987= Chiron patents genome
2012= DAAs
2014= Sofosbavir