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Flashcards in gold usmle: Diseases Deck (146)
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31

Crohn’s

IBD; ileocecum, transmural, skip lesions, cobblestones, lymphocytic infiltrate, granulomas
44. (contrast to UC: limited to colon, mucosa & submucosa, crypt abscesses, pseudopolyps, ↑ colon cancer risk)
45. Clinically: ab pain & diarrhea; fever; malabsorption; fistulae b/t intestinal loops & abd structures

32

Curling’s Ulcer

Acute gastric ulcer associated with severe burns

33

Cushing’s

Disease: Hypercorticism 2° to ↑ ACTH from pituitary (basophilic adenoma)
48. Syndrome: hypercorticism of all other causes (1° adrenal or ectopic)
49. - moon face; buffalo hump; purple striae; hirsutism; HTN; hyperglycemia

34

Cushing’s Ulcer

Acute gastric ulcer associated with CNS trauma

35

de Quervain’s Thyroiditis

Self-limiting focal destruction (subacute thyroiditis)

36

DiGeorge’s Syndrome

Failure of 3rd & 4th pharyngeal pouches formation: Thymus & Parathyroid
53. Thymic hypoplasia → T-cell deficiency
54. Hypoparathyroidism ! Tetany

37

Down’s Syndrome

Trisomy 21 or translocation – Simian Crease

38

Dressler’s Syndrome

Post-MI Fibrinous Pericarditis autoimmune

39

Dubin-Johnson Syndrome

Congenital hyperbilirubinemia (conjugated) = bilirubin transposrt is defective not conjugation
58. Striking brown-to-black discoloration of the liver

40

Duchenne Muscular Dystrophy

Deficiency of dystrophin protein → MD X-linked recessive

41

Edwards’ Syndrome

60. Trisomy 18
61. Rocker-bottom feet, low ears, small lower jaw, heart disease

42

Ehler’s-Danlos

Defective collagen

43

Eisenmenger’s Complex

Late cyanotic shunt (R→L) pulmonary HTN & RVH 2° to long-standing VSD, ASD, or PDA

44

Erb-Duchenne Palsy

Trauma to superior trunk of brachial plexus Waiter’s Tip
C5-C6

45

Ewing Sarcoma

Malignant undifferentiated round cell tumor of bone in boys

46

Eyrthroplasia of Queyrat

Carcinoma in situ on glans penis

47

Fanconi’s Syndrome

Impaired proximal tubular reabsorption 2° to lead poisoning or Tetracycline (glycosuria,
hyperphosphaturia, aminoaciduria, systemic acidosis)

48

Felty’s Syndrome

Rheumatoid arthritis, neutropenia, splenomegaly

49

Gardner’s Syndrome

AD = adenomatous polyps of colon, osteomas & soft tissue tumors

50

Gaucher’s Disease

Lysosomal Storage Disease glucocerebrosidase deficiency – glucocerebroside accumulation
71. Hepatosplenomegaly, femoral head & long bone erosion, anemia

51

Gilbert’s Syndrome

Benign congenital hyperbilirubinemia (unconjugated) = ↓d glucuronyl transferase activity

52

Glanzmann’s Thrombasthenia

Defective glycoproteins on platelets = deficient platelet aggregation

53

Goodpasture’s

Autoimmune: ab’s to glomerular & alveolar basement membranes. Seen in men in their 20’s

54

Grave’s Disease

Autoimmune hyperthyroidism (TSI): IgG Ab reactive w/ TSH receptors. Low TSH & TRH – High T3 / T4

55

Guillain-Barre

Polyneuritis following viral infection/ autoimmune (ascending muscle weakness & paralysis; usually self-limiting)

56

Hamman-Rich Syndrome

Idiopathic pulmonary fibrosis. Can see honey comb lung.

57

Hand-Schuller-Christian

Chronic progressive histiocytosis

58

Hashimoto’s Thyroiditis

Autoimmune hypothyroidism. May have transient hyperthyroidism. Low T3 /T4 & High TSH

59

Hashitoxicosis

Initial hyperthyroidism in Hashimoto’s Thyroiditis that precedes hypothyroidism

60

Henoch-Schonlein purpura

Hypersensivity vasculitis = allergic purpura. Lesions have the same age.
82. Hemmorhagic urticaria (with fever, arthralgias, GI & renal involvement)
83. Associated with upper respiratory infections