Flashcards in gold usmle: Diseases Deck (146)
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31
Crohns
IBD; ileocecum, transmural, skip lesions, cobblestones, lymphocytic infiltrate, granulomas
44. (contrast to UC: limited to colon, mucosa & submucosa, crypt abscesses, pseudopolyps, ↑ colon cancer risk)
45. Clinically: ab pain & diarrhea; fever; malabsorption; fistulae b/t intestinal loops & abd structures
32
Curlings Ulcer
Acute gastric ulcer associated with severe burns
33
Cushings
Disease: Hypercorticism 2° to ↑ ACTH from pituitary (basophilic adenoma)
48. Syndrome: hypercorticism of all other causes (1° adrenal or ectopic)
49. - moon face; buffalo hump; purple striae; hirsutism; HTN; hyperglycemia
34
Cushings Ulcer
Acute gastric ulcer associated with CNS trauma
35
de Quervains Thyroiditis
Self-limiting focal destruction (subacute thyroiditis)
36
DiGeorges Syndrome
Failure of 3rd & 4th pharyngeal pouches formation: Thymus & Parathyroid
53. Thymic hypoplasia → T-cell deficiency
54. Hypoparathyroidism ! Tetany
37
Downs Syndrome
Trisomy 21 or translocation Simian Crease
38
Dresslers Syndrome
Post-MI Fibrinous Pericarditis autoimmune
39
Dubin-Johnson Syndrome
Congenital hyperbilirubinemia (conjugated) = bilirubin transposrt is defective not conjugation
58. Striking brown-to-black discoloration of the liver
40
Duchenne Muscular Dystrophy
Deficiency of dystrophin protein → MD X-linked recessive
41
Edwards Syndrome
60. Trisomy 18
61. Rocker-bottom feet, low ears, small lower jaw, heart disease
42
Ehlers-Danlos
Defective collagen
43
Eisenmengers Complex
Late cyanotic shunt (R→L) pulmonary HTN & RVH 2° to long-standing VSD, ASD, or PDA
44
Erb-Duchenne Palsy
Trauma to superior trunk of brachial plexus Waiters Tip
C5-C6
45
Ewing Sarcoma
Malignant undifferentiated round cell tumor of bone in boys
46
Eyrthroplasia of Queyrat
Carcinoma in situ on glans penis
47
Fanconis Syndrome
Impaired proximal tubular reabsorption 2° to lead poisoning or Tetracycline (glycosuria,
hyperphosphaturia, aminoaciduria, systemic acidosis)
48
Feltys Syndrome
Rheumatoid arthritis, neutropenia, splenomegaly
49
Gardners Syndrome
AD = adenomatous polyps of colon, osteomas & soft tissue tumors
50
Gauchers Disease
Lysosomal Storage Disease glucocerebrosidase deficiency glucocerebroside accumulation
71. Hepatosplenomegaly, femoral head & long bone erosion, anemia
51
Gilberts Syndrome
Benign congenital hyperbilirubinemia (unconjugated) = ↓d glucuronyl transferase activity
52
Glanzmanns Thrombasthenia
Defective glycoproteins on platelets = deficient platelet aggregation
53
Goodpastures
Autoimmune: abs to glomerular & alveolar basement membranes. Seen in men in their 20s
54
Graves Disease
Autoimmune hyperthyroidism (TSI): IgG Ab reactive w/ TSH receptors. Low TSH & TRH High T3 / T4
55
Guillain-Barre
Polyneuritis following viral infection/ autoimmune (ascending muscle weakness & paralysis; usually self-limiting)
56
Hamman-Rich Syndrome
Idiopathic pulmonary fibrosis. Can see honey comb lung.
57
Hand-Schuller-Christian
Chronic progressive histiocytosis
58
Hashimotos Thyroiditis
Autoimmune hypothyroidism. May have transient hyperthyroidism. Low T3 /T4 & High TSH
59
Hashitoxicosis
Initial hyperthyroidism in Hashimotos Thyroiditis that precedes hypothyroidism
60
