Immunotherapies Flashcards Preview

AH extra cards > Immunotherapies > Flashcards

Flashcards in Immunotherapies Deck (33)
Loading flashcards...
1

3 immune stimulators

1. G-CSF/GM-CSF
2. IL-2
3. alpha, beta, gamma interferons

2

Action of G/GM-CSF

Stimulates bone marrow to produce mature neutrophils

3

Action of IL-2

T cell activation

4

What are interferons used to treat?

Alpha= hep C
Beta= MS
Gamma= intracellular infection, chronic granulomatous disease, IL-12 deficiency

5

3 main types immunosuppression

Corticosteroids
Lymphocyte targeting
DMARDS

6

7 actions of corticosteroids

1. margination of neutrophils
2. decrease cytokines
3. lymphopenia
4. toxic to t cells
5. inhibit phospholipase A2
6. Decreased T cell proliferation
7. Ig production decreased

7

4 uses of corticosteroids

Allograft, autoimmune, inflammatory, malignancies

8

5 side effects of corticosteroids

Diabetes and hyperlipidaemia
Decreased protein synthesis (wound repair worse)
OSteoporosis
Glaucoma and cataracts
Psychiatric

9

4 types of lymphocyte targeting therapies

Antimetabolites/cytotoxic
Calcineurin inhibitors
m-TOR inhibitors
IL-2 receptor mABs

10

Action of antimetabolites

Inhibit purine synthesis so B and T cells inhibited

11

Uses of antimetabolites

Allograft and autoimmune

12

Side effects of antimetabolites

BM suppression
Gastric upset
Hepatitis
Infection

13

What does calcineurin do?

Activates T cells

14

Action of mTOR inhibitors

Inhibit response to IL2 --> T cell cycle arrest

15

Name of mTOR inhibitor

Sirolimus/rapamycin

16

Uses of mTOR and calc inhibitors

TRansplant and autoimmune

17

Side effects of mTOR and calc inhibitors (8)

HTN
Hirtuism
Nephrotoxic
Hepatotoxic
Lyphomas
Infection
NEurotoxic
Drug interaction

18

5 types DMARDs

Anticytokines
Rituximab
Anti T cell
Anti adhesion
Anti complement

19

Uses of anticytokines

RA, AOSD, Crohns, psoriasis

20

Side effects of anticytokines

TB, serum lipid control

21

3 types of anticytokines

Anti: TNF, IL-1, IL-6

22

Action of Rituximab

Against CD20 on B cells

23

Uses of Rituximab

Autoimmune, allograft, leukaemia, lymphoma

24

What are immunomodulators used for?

Allergies

25

5 types immunomodulators?

Steroids
Immune suppressants
Allergen specific immunotherapy
Anti IgE monoclonal therapy
Anti IL-5 monoclonal therapy

26

Why would you use allergen specific immunodeficiency

Anaphylaxis to insects
Uncontrollable rhino-conjunctivitis

27

Action of allergen specific immunodeficiency

Immune response switched from Th2 --> Th1

28

Side effect of allergen specific immunodeficiency

Allergic reaction

29

e.g. of Anti IgE therapy

Omalizumab

30

Omalizumab use

Asthma, urticaria, angioedema