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Flashcards in Immunotherapies Deck (33):
1

3 immune stimulators

1. G-CSF/GM-CSF
2. IL-2
3. alpha, beta, gamma interferons

2

Action of G/GM-CSF

Stimulates bone marrow to produce mature neutrophils

3

Action of IL-2

T cell activation

4

What are interferons used to treat?

Alpha= hep C
Beta= MS
Gamma= intracellular infection, chronic granulomatous disease, IL-12 deficiency

5

3 main types immunosuppression

Corticosteroids
Lymphocyte targeting
DMARDS

6

7 actions of corticosteroids

1. margination of neutrophils
2. decrease cytokines
3. lymphopenia
4. toxic to t cells
5. inhibit phospholipase A2
6. Decreased T cell proliferation
7. Ig production decreased

7

4 uses of corticosteroids

Allograft, autoimmune, inflammatory, malignancies

8

5 side effects of corticosteroids

Diabetes and hyperlipidaemia
Decreased protein synthesis (wound repair worse)
OSteoporosis
Glaucoma and cataracts
Psychiatric

9

4 types of lymphocyte targeting therapies

Antimetabolites/cytotoxic
Calcineurin inhibitors
m-TOR inhibitors
IL-2 receptor mABs

10

Action of antimetabolites

Inhibit purine synthesis so B and T cells inhibited

11

Uses of antimetabolites

Allograft and autoimmune

12

Side effects of antimetabolites

BM suppression
Gastric upset
Hepatitis
Infection

13

What does calcineurin do?

Activates T cells

14

Action of mTOR inhibitors

Inhibit response to IL2 --> T cell cycle arrest

15

Name of mTOR inhibitor

Sirolimus/rapamycin

16

Uses of mTOR and calc inhibitors

TRansplant and autoimmune

17

Side effects of mTOR and calc inhibitors (8)

HTN
Hirtuism
Nephrotoxic
Hepatotoxic
Lyphomas
Infection
NEurotoxic
Drug interaction

18

5 types DMARDs

Anticytokines
Rituximab
Anti T cell
Anti adhesion
Anti complement

19

Uses of anticytokines

RA, AOSD, Crohns, psoriasis

20

Side effects of anticytokines

TB, serum lipid control

21

3 types of anticytokines

Anti: TNF, IL-1, IL-6

22

Action of Rituximab

Against CD20 on B cells

23

Uses of Rituximab

Autoimmune, allograft, leukaemia, lymphoma

24

What are immunomodulators used for?

Allergies

25

5 types immunomodulators?

Steroids
Immune suppressants
Allergen specific immunotherapy
Anti IgE monoclonal therapy
Anti IL-5 monoclonal therapy

26

Why would you use allergen specific immunodeficiency

Anaphylaxis to insects
Uncontrollable rhino-conjunctivitis

27

Action of allergen specific immunodeficiency

Immune response switched from Th2 --> Th1

28

Side effect of allergen specific immunodeficiency

Allergic reaction

29

e.g. of Anti IgE therapy

Omalizumab

30

Omalizumab use

Asthma, urticaria, angioedema

31

Omalizumab side effect

Anaphylaxis

32

Name of anti IL-5 therapy

mepolizumab

33

mepolizumab action

Inhibits eosinophils