Flashcards in More CP Deck (92)
What is haematocrit?
Vol % rbcs in blood
Is haematocrit higher or lower in children?
Zeta + epsilon = what sort of Hb?
Zeta + gamma =?
Alpha + epsilon
Hb gower 1 is ?
Zeta + epsilon
Hb Portland is ?
Zeta + gamma
Hb gower 2 is ?
Alpha + epsilon
When are Hbs gower1, portland and gower 2 present?
4-14 weeks gestation
When does HbF become present?
more than 14 weeks gestation
Difference in WBCs in children?
Which Ig crosses the placenta?
Which Igs in breast milk?
When do babies start producing their own antibodies?
When can babies have their own satisfactory immune responses?
When do platelets reach adult numbers?
18 weeks gestation
What are 2 features of gestational platelets?
Larger initially but reduce to adult size by birth
Hyperresponsive to vWF
Which clotting factors are normal at birth? What are the rest of them like?
Fibrinogen, FV, VIII, XIII
Rest are reduced
When do haemostatic parameters reach adult values?
What is vitamin k dependent other than factors 10, 7, 9, 2?
Proteins S and C
What does routine neonatal vit k injections prevent?
Haemorrhagic disease of the newborn
What are 5 features of neonatal haemostasis?
Pro-coagulant proteins reduced (e.g. all the other factors)
Reduced conc. coagulation inhibitors
unique forms fibrinogen, plasminogen
Raised D dimers and vWF
Platelet aggregation differs
What is acute leukaemia?
Accumulation of early myeloid or lymphoid precursors in BM, blood and other tissues
What are the two main subgroups of acute leukaemia
Acute myeloid leukaemia and acute lymphoblastic leukaemia
How does acute leukaemia present?
Easy bruising or haemorrhage
Possibly organ infiltration by the leukaemia cells
FAB classification of leukaemia is ?
WHO classification of leukaemia is ?
Risk adapted- takes into account prognosis
6 poor prognostic factors in ALL?
Cytogenetic abnormalities (some)
Poor response to Rx
T cell -ALL and null-ALL
2 tests for diagnosis?
Fluorescence activated cell sorting