JAALAS 2012 No.1 Flashcards Preview

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Flashcards in JAALAS 2012 No.1 Deck (43)
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1

The guinea pig is a more appropriate model for human parturition.

True - In contrast to mice, maternal levels of progesterone do not fall at term in humans or guinea pigs.

2

Generally speaking estrogen is responsible for pregnancy and myometrial quiescence.

False - Progesterone is associated with the above findings. Estrogen is thought to precipitate labor through inciting prostaglandin and oxytocin synthesis.

3

Oxytocin should be administered IP.

False - It is best administered SQ, buccal and nasal. IP is contraindicated because it is difficult in gravid mice. In addition oral administration is ineffective because the stomach rapidly destroys the hormone.

4

Oxytocin should not be used to treat dystocia where an obstruction exists.

True - If this is done it can lead to titanic uterine contractions, placental separation, uterine rupture and hemorrhage.

5

1. Which of the following methods can be used as stress indicators in mice?
a. Level of corticosteroids in urine
b. Stereotypic behavior
c. Immature (CD4+, CD8+) counts in thymus
d. All of the above

D

6

2. What is duration of aimless, repetitive behaviors before it can be considered as stereotypic behavior?
a. 10 minutes
b. 60 minutes
c. 10 seconds
d. 30 seconds

C

7

3. T/F. This study showed that use of nesting materials did not have any deleterious effect on mouse physiological or immunological parameters.

False

8

Chlordiazepoxide is what class of drug?
a. Opioid
b. Benzodiazepine
c. Antihistamine
d. Barbiturate

b. Benzodiazepine; it is the anxiolytic drug given to the rats in the conditioned place preference test in this study

9

How did the authors intend the use of environmental enrichment (chew toy) by the rats to support their hypothesis?

Use of environmental enrichment is decreased in chronically stressed rats. If no decrease in use was seen between groups, than that would be indirect support that the procedure did not cause chronic stress.

10

Fecal corticosterone levels reflect hormonal states occurring in what time frame?
a. 1-2 hours previously
b. 3-5 hours previously
c. 6-8 hours previously
d. 12-14 hours previously

c. 6-8 hours previously

11

1. True or false. The study demonstrated highest agreement between raters for juveniles.

False

12

2. Which of these is not a key anatomical site used in BCS palpation?
a. Hips
b. Spine
c. Pelvis
d. Head
e. Thorax
f. Abdomen

D

13

T/F – Syphacia obvelata does not generally cause eosinophilia in mice, but Rodentolepis nana does.

True

14

Based on the results of this study, which group of animals may harbor transmissible diseases that are more similar to colony mice in a lab animal facility?
a. Urban feral mice
b. Pet store mice

Pet store mice

15

Which of these agents is a zoonotic concern? (Choose all that apply)
a. R. nana
b. E. faecium
c. Myocoptes musculinis
d. Lymphocytic choriomeningitis

A, B, and D

16

1. Pain-relevant behaviors are twitching, back arching, stagger or fall, and writhing

True

17

2. Pain-relevant behaviors can be observed for 24 hours after surgery.

2. False. Pain-relevant behaviors can be observed for 2 to 6 hours after surgery.

18

3. Buprenorphine abolished completely facial grimacing at doses of 0.05 and 0.1 mg/kg.

True

19

4. The current findings reveal no evidence of analgesia from acetaminophen at doses ranging from 100 to 450 mg/kg.

True

20

True or False: Humans and mice have the same CO2 receptors in the nasal mucosa.

True

21

Which of the following is the most humane method of euthanasia based on the findings in this article?
a. Acepromazine 5mg/kg followed by CO2
b. Midazolam 5mg/kg followed by CO2
c. 5% Isoflurane followed by CO2
d. CO2 alone.

D

22

True or False: 20% V/min CO2 alone is not considered a humane method of euthanasia in laboratory mice.

False (This is only true according to the CCAC and Morris Foundation)

23

True or False. An initial intraperitoneal dose of sodium pentobarbital provides approximately 60 to 120 min of anesthesia.

True

24

ABS means:
a. Hypnosis-based sedation
b. Anesthesia based-sedation
c. Analgesia based-sedation
d. Constant rate infusion anesthesia
e. All of them are true

B

25

True or False. Opioids are administered parenterally, intravenously, orally, and even intrathecally in laboratory animals.

True

26

In ABS, analgesics are used to:
a. To maximize comfort
b. To minimize distress
c. To provide deep sedation simultaneously
d. All of them are right

D

27

Which factors should be considered when administering sedatives to laboratory animals?
a. Experimental time course
b. Drug delivery system chosen for the type of experimental procedure
c. Animal size
d. All of them are factors

D

28

1. Pigs can be maintained in an ICU for as long as ______ days?
a. 5 days
b. 3 days
c. 7 days
d. 10 days

C

29

2. True or False: The Richmond agitation-sedation scale (RASS) was found to be an excellent model for evaluating sedation in mechanically ventilated swine ICU models?

False

30

Which of the following signs is NOT associated with abdominal pain in mice?
a. Writhe
b. Abdominal press
c. Increased grooming
d. Twitch

Increased grooming