JAALAS 2012 No. 3

Question 1

The 2011 Guide recommends that rabbit cages be a minimum of ____ inches in height.

a. 12
b. 14
c. 16
d. 24

Answer 1

C

Question 2

Phase in period for significant equipment replacement is until__

a. September 2014
b. July 2014
c. September 2015
d. July 2015

Answer 2

A

Question 3

According to the 2011 Guide, performance based standards need to be reviewed at minimum how frequently by the oversight body?

a. Every 6 months or during the program review
b. At minimum every year
c. At minimum every 3 years
d. No set monitoring time frame is stated.

Answer 3

D

Question 4

All animals owned by the accreditable unit are to be reported in the Program Description. T or F

Answer 4

True

Question 5

The Guide, Ag Guide, and ETS 123 differ significantly in their recommendations for cage and pen space. T or F

Answer 5

True

Question 6

Which is the current adopted edition of the Ag Guide?

a. Second edition
b. Sixth edition
c. Ninth edition
d. First edition
e. Third edition

Answer 6

E

Question 7

True or False? The full name of the current “Ag Guide” is, Guide for the care and Use of Agricultural Animals in Research and Training?.

Answer 7

False. Guide for the care and Use of Animals in Research and Training.

Question 8

True or False? The Ag Guide should be used solely by institutions with agricultural animals in caring for and using these animals in ways judged to be scientifically, technically and humanely appropriate.

Answer 8

False. It should be used in concert with other primary standard guides.

Question 9

The Inspection Requirements Handbook includes 2 additional sections. True or false

Answer 9

True

Question 10

The inspections of research facilities are conducted by the Veterinary Medical Officer (VMO) working under one of the Animal Care Regional Supervisors. True or false

Answer 10

True

Question 11

The 2008 amendment to the AWA increased the maximal fine for violations of the AWA from $2500 to $8,000.

Answer 11

False

Question 12

What is the Freedom of Information Act’s intent?

Answer 12

The FOIA’s intent is to promote open government and allow for holding government officials accountable for decisions which are made

Question 13

When was the FOIA enacted?

Answer 13

1966

Question 14

How many exemptions does the FOIA have, and which are most pertinent to the protection of sensitive personal information in biomedical research?

Answer 14

9 exemptions. Exemption #4, #6, #7 are the exemptions used most frequently to prevent personal/sensitive information from being disclosed

Question 15

A few abbreviations are used in this article. Define: FELASA, ECLAM, ESLAV

Answer 15

Federation of European Laboratory Animal Science Associations; European College of Laboratory Animal Medicine; European Society of Laboratory Animal Veterinarians

Question 16

Where can you find FELASA guidelines and reports?

Answer 16

Most are submitted for publication in the FELASA journal Laboratory Animals Limited; when the report cannot be published, they are made available on the FELASA and Laboratory Animals Limited websites

Question 17

True or False: FELASA represents government organizations, therefore the reports produced by FELASA are regulatory in nature.

Answer 17

False

Question 18

1. What is an adequate ethical justification for which the Guide would waive prohibition on multiple major surgeries on the same animal?
   a. Cost of multiple animals
   b. Conserving members of a rare species
   c. Research budget restrictions

Answer 18

B

Question 19

2. The difference between a performance standard and an engineering standard is that the former will state requirements in terms of results but will not sate which methods need to be used to achieve the goal, when instead the latter will set also the methods to achieve it.
   a. True
   b. False

Answer 19

A

Question 20

3. In the Guide the jurisdictional standard for veterinarians is clearly defined in the case of emergency veterinary care. Chose the more appropriate statement that defines such standard:
   a. The veterinarian must have the authority delegated by senior administration to treat an animal in need even when the investigator is not available
   b. The veterinarian should have authority to treat animals in need only when the investigator has been consulted by the IACUC
   c. The Institutional Official must have the authority to treat animals without consultation of the attending veterinarian

Answer 20

A

Question 21

Why should sick aquatic animals be moved to different housing for antibiotic treatment?

Answer 21

Antibiotics in the system are detrimental to nitrifying bacteria and can have negative effects on water quality and colony health.

Question 22

What is the first thing to assess when abnormalities are noted in aquatic/semiaquatic species:

a. Photoperiod length
b. Contamination of the commercial feed
c. Sentinels
d. Water quality

Answer 22

D

Question 23

1. The primary point of contact for the entity with the CDC and APHIS is called the:
   a. Institutional Official
   b. Responsible Official
   c. Accountable Official
   d. Executive Official

Answer 23

B

Question 24

2. The Security Risk Assessment to ensure that restricted persons do not gain access to the agents and toxins is conducted via the:
   a. CIA
   b. USDA
   c. CDC
   d. FBI

Answer 24

D

Question 25

1. T/F Nonsocial enrichment programs reduce physiologic indicators of stress in female Sprague- Dawley rats.

Answer 25

False

Question 26

2. Environmental enrichment has been shown to enhance special memory performance following traumatic brain injury in which of the following groups: a. Female rats b. Male rats

Answer 26

B

Question 27

3. In Sprague-Dawley female rats, enrichment significantly increased systolic blood pressure responses to: a. One hour restraint and cage change b. Handling and odors of male c. Subcutaneous injection and removal of casemates d. Transport and subcutaneous injection

Answer 27

C

Question 28

Blood samples collected from the lateral tail vein had ____, in comparison to the jugular vein drawn samples. a. Higher levels of plasma thrombin-antithrombin complexes b. Greater hemolysis of erythrocytes c. Higher levels of plasma hemoglobin d. All of the above

Answer 28

D

Question 29

C reactive protein is elevated in blood due to inflammation-associated tissue injury, and was found to be ____ in tail samples, indicating ___, than was found in jugular collected samples. a. Lower, less inflammation of tissue. b. Higher, potentially more inflammation of tissue c. The same, no difference in inflammation of tissue

Answer 29

B

Question 30

What 4 criteria did authors state the technique fulfilled, making it a useful refinement of experimental technique?

Answer 30

Anesthesia was not required, able to use the technique for serial collections, ability to acquire a large-volume, high quality sample, and supported the preservation of the health and well being of the animal

Question 31

T/F. The use of isoflurane is a confounding element in this study.

Answer 31

True - it causes muscle relaxation which could change the outcome and it prevents mice from returning to consciousness after a dislocation that does not cause death

Question 32

T/F. Cecal ligation and puncture (CLP) is a surgical technique in mice used to induce polymicrobial sepsis which reproduces the dynamic clinical changes seen in human sepsis.

Answer 32

True

Question 33

Which of the following statements best describes morphine and its immunomodulatory activity in rodents? a. Morphine is a partial mu receptor agonist which decreases corticosteroid secretion b. Morphine is a mu receptor agonist with limited immunomodulatory effects c. Morphine is a mu receptor agonist and kappa antagonist which increases pro inflammatory mediators d. Morphine is a mu receptor agonist associated with increased endotoxin sensitivity e. Morphine is a mu receptor agonist which increases gut motility and bacterial translocation

Answer 33

D

Question 34

Which of the following statements is most accurate? a. Responses to sepsis do not significantly differ between male and female mice, which is in contrast to differences seen in men and women b. Male and female C57BL/6 mice exhibit sex differences in nociceptive and immunomodulatory responses to morphine which are identical to those seen with buprenorphine c. Both of the above d. Neither of the above

Answer 34

D