JAALAS 2011 No. 5 Flashcards Preview

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Flashcards in JAALAS 2011 No. 5 Deck (64)
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1

1. What is the optimal oral dosage to avoid gastric distention?

5 mL/kg regardless of the species.

2

2. What is the most efficient method for administering compounds and why?

2. Intravenous administration because it bypasses the need for solute absorption.

3

3. Name four routes of administration that go through the skin.

3. Intramuscular, intravenous, subcutaneous and intradermal.

4

4. What is the advantage of epidural and intrathecal administration?

4. Avoids absorptive problems associated with the blood-brain barrier.

5

5. What are the risks of improper training for intraperitoneal injections?

Intracecal or intracystic injections.

6

6. What are the three methods for pulmonary administration of solutions?

6. Intranasal, intratracheal and inhalation.

7

7. T/F. Training or habituation is of no benefit when preparing for dosing of animals.

7. False. Animals have a stress response when they are not used to being handled, so handling and restraint is helpful prior to substance administration.

8

8. T/F. The temperature of a solution is not relevant when the volumes are small.

8. False. Larger volumes of a cold or hot substance would be more detrimental, but even small volumes could have different absorption if at extreme temperatures.

9

1. A homogeneous fluid mixture of 2 or more substances that cannot be readily separated is a ___________________.

Solution

10

2. A final mixture that is prepared for dosing is termed:
a. Formulation
b. Solution
c. Suspension
d. Vehicle

A

11

3. List at least 3 devices that can be used as rodent restraint devices.

3. Broome tube, plastic cone shaped bags, towels, slings

12

4. How often should ports be flushed?
a. Once a day
b. Every 4 hours
c. Every 3-4 days
d. Every 7 days if actively using

4. c. Every 3-4 days for the first 2 weeks after implantation; thereafter every 7-14 days if port is not actively used.

13

5. All of the following are acceptable nonhuman primate restraint devices except:
a. Restrain tubes
b. Chairs
c. Pole and collar restraint
d. Squeeze back caging
e. Panepinto sling

E

14

6. When should bags of open sterile intravenous fluids be discarded?

6. Within one week of first use or opened

15

List commonly used cosolvents

Ethanol, propylene glycol, polyethylene glycol and glycerine

16

8. True or False. Cosolvents should be given as a slow injection or infusion due to the potential for the drug to precipitate once administered.

True

17

T or F. The femoral arteries branch off of the iliac artery proximal to the branching of the circumflex iliac.

False - The femoral arteries (external and internal) branch off of the iliac artery distal the branching the circumflex iliac.

18

What is the mechanism of action of heparin?

Heparin facilitates the endogenous serine protease inhibitor ATIII by bind the aminolysyl residues and heparin cofactor II. These anticoagulants form stable complexes and subsequently inhibit clotting factors (thrombin being the most important).

19

1. Establishment of reference ranges of for hematology and serum biochemical analytes may be affected by which one of the following?
a. Water temperature or other environmental factors
b. Source of animals
c. Health of the animals
d. All of the above
e. None of the above

D

20

2. Significant differences were found between 3 X. laevis populations for all hematological values measured except one. Which value was not significantly different?
a. Mean corpuscular hemoglobin
b. WBC count
c. Hematocrit
d. Mean corpuscular volume
e. RBC count

A

21

3. Significant differences were not found between 2 X. laevis populations for all of the following serum biochemical analytes except one. Which value was significantly different?
a. BUN
b. Alkaline phosphatase
c. Phosphorus
d. Glucose
e. Uric acid

D

22

1. Fostering alone or as part of Caesarian rederivation procedures has been used to eradicate all of the following diseases EXCEPT?
a. Norovirus
b. Lymphocytic Choriomeningitis Virus
c. Helicobacter spp.
d. Mouse Coronavirus

1. C. This technique is not useful for the eradication of pathogens that are passed in utero

23

2. Current laboratory animal medicine practice recommends fostering pups within ____ h of birth to recipient dams with age-matched litters.
a. 48
b. 72
c. 96
d. 120

A

24

According to this study individually ventilated cages housing female opossums with litters should be changed once every 7 days. True or false?

True

25

What was the average weight of male opossums used in study?
a. 500 g
b. 400 g
c. 300 g
d. 127 g

D

26

The dimensions of the Individually ventilated caging used for this study are usually used to house rats. True or False

True

27

In this study the cages were ventilated at 60 air changes per hour. True or False

True

28

Acceleration is measured with the use of:
a. A traffic-cop speedometer
b. An accerometer
c. A velometer

A

29

The noise and the vibration associated with construction surrounding an animal facility are equally concerning, T or F?

F - vibration is likely of greater concern

30

Resources for Vertebrate Animal Biosafety Level Criteria for Vivarium Research Facilities

BLMB or http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5_sect_V.pdf