Flashcards in Last part Deck (26):
B cells provides signal ... for the activation of lyphocytes
what signals do innate molecules respond to?
What do IFN a/b trigger?
response to intracellular TLF signaling and other sensors of viral RNA
What does IFN a/b activate?
JAK STAT on neighboring uninfected cell, this produces expression of genes whose products interfere with viral replication
What is a plasma protine that microbial strucutes and particifpates in innate immunity?
What are in the petraxin family?
c reactive protins CRP and serum amyloid P SAP
WHat is the results of IL6 and IL1 in the liver?
increased amounts of CRP and SAP
What does CRP and SAP do?
recognize phosphorylcholine and phosphatidylethanolamine, which are found on bacteria and apoptotic cells
What can CRP and SAM activate?
complement by bdinging C1q and intiating the classical pathway
complement pathways results in
complement proteins into protease complexes
What cleaves the centra protine of the complement system?
C3 convertse cleaves C3 and makes
C3a and C3b
What does the C3b fragment become?
covalently attached to the microbial surface
What serves as an opsonin to promoe phagocytosis of the microbes?
What does the C3b fragment do?
stimulates inflammation by acting as a chemoattractant for neutrophils
C3b also cleaves to?
C5 convertase that cleaves C5,
What does C5 cleaved generated?
a releasted peptide C5a dn a larger fragment C5b that remains attached to the microbial cell membrane
WHat is a very potent chemoattractant that slo induces changes in the permeability of blood vessels?
What complex does C5b initiate?
C6,7, 8, 9
What is the complex called
How does classical pathway work?
uses plams protein called C1q to detect Abs bound to the surface of a microbe or other sturucture
What does C1q do?
binds to the Fc portion of the antibodies, tw associated with serin proteases C1r and C1s become active
What initiates a proteolytic cascade invloing other complement protins C2 and C4 in the classical pathway?
C1r and C1s
C1s adds to C4 to make C4b
C1s adds to C2 to make C2a
C4b and C2a bind and make
c3 convertase of the classical pathway