Last part Flashcards Preview

Undeleted > Last part > Flashcards

Flashcards in Last part Deck (26):
1

B cells provides signal ... for the activation of lyphocytes

1

2

what signals do innate molecules respond to?

2

3

What do IFN a/b trigger?

response to intracellular TLF signaling and other sensors of viral RNA

4

What does IFN a/b activate?

JAK STAT on neighboring uninfected cell, this produces expression of genes whose products interfere with viral replication

5

What is a plasma protine that microbial strucutes and particifpates in innate immunity?

pentraxin family

6

What are in the petraxin family?

c reactive protins CRP and serum amyloid P SAP

7

WHat is the results of IL6 and IL1 in the liver?

increased amounts of CRP and SAP

8

What does CRP and SAP do?

recognize phosphorylcholine and phosphatidylethanolamine, which are found on bacteria and apoptotic cells

9

What can CRP and SAM activate?

complement by bdinging C1q and intiating the classical pathway

10

complement pathways results in

complement proteins into protease complexes

11

What cleaves the centra protine of the complement system?

C3 convertase

12

C3 convertse cleaves C3 and makes

C3a and C3b

13

What does the C3b fragment become?

covalently attached to the microbial surface

14

What serves as an opsonin to promoe phagocytosis of the microbes?

C3b

15

What does the C3b fragment do?

stimulates inflammation by acting as a chemoattractant for neutrophils

16

C3b also cleaves to?

C5 convertase that cleaves C5,

17

What does C5 cleaved generated?

a releasted peptide C5a dn a larger fragment C5b that remains attached to the microbial cell membrane

18

WHat is a very potent chemoattractant that slo induces changes in the permeability of blood vessels?

C5a

19

What complex does C5b initiate?

C6,7, 8, 9

20

What is the complex called

mac

21

How does classical pathway work?

uses plams protein called C1q to detect Abs bound to the surface of a microbe or other sturucture

22

What does C1q do?

binds to the Fc portion of the antibodies, tw associated with serin proteases C1r and C1s become active

23

What initiates a proteolytic cascade invloing other complement protins C2 and C4 in the classical pathway?

C1r and C1s

24

C1s adds to C4 to make C4b

C1s adds to C2 to make C2a

25

C4b and C2a bind and make

c3 convertase of the classical pathway

26

What triggers the leptin pathway?

mannose-binding lectin