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Flashcards in Last part Deck (26)
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1
Q

B cells provides signal … for the activation of lyphocytes

A

1

2
Q

what signals do innate molecules respond to?

A

2

3
Q

What do IFN a/b trigger?

A

response to intracellular TLF signaling and other sensors of viral RNA

4
Q

What does IFN a/b activate?

A

JAK STAT on neighboring uninfected cell, this produces expression of genes whose products interfere with viral replication

5
Q

What is a plasma protine that microbial strucutes and particifpates in innate immunity?

A

pentraxin family

6
Q

What are in the petraxin family?

A

c reactive protins CRP and serum amyloid P SAP

7
Q

WHat is the results of IL6 and IL1 in the liver?

A

increased amounts of CRP and SAP

8
Q

What does CRP and SAP do?

A

recognize phosphorylcholine and phosphatidylethanolamine, which are found on bacteria and apoptotic cells

9
Q

What can CRP and SAM activate?

A

complement by bdinging C1q and intiating the classical pathway

10
Q

complement pathways results in

A

complement proteins into protease complexes

11
Q

What cleaves the centra protine of the complement system?

A

C3 convertase

12
Q

C3 convertse cleaves C3 and makes

A

C3a and C3b

13
Q

What does the C3b fragment become?

A

covalently attached to the microbial surface

14
Q

What serves as an opsonin to promoe phagocytosis of the microbes?

A

C3b

15
Q

What does the C3b fragment do?

A

stimulates inflammation by acting as a chemoattractant for neutrophils

16
Q

C3b also cleaves to?

A

C5 convertase that cleaves C5,

17
Q

What does C5 cleaved generated?

A

a releasted peptide C5a dn a larger fragment C5b that remains attached to the microbial cell membrane

18
Q

WHat is a very potent chemoattractant that slo induces changes in the permeability of blood vessels?

A

C5a

19
Q

What complex does C5b initiate?

A

C6,7, 8, 9

20
Q

What is the complex called

A

mac

21
Q

How does classical pathway work?

A

uses plams protein called C1q to detect Abs bound to the surface of a microbe or other sturucture

22
Q

What does C1q do?

A

binds to the Fc portion of the antibodies, tw associated with serin proteases C1r and C1s become active

23
Q

What initiates a proteolytic cascade invloing other complement protins C2 and C4 in the classical pathway?

A

C1r and C1s

24
Q

C1s adds to C4 to make C4b

A

C1s adds to C2 to make C2a

25
Q

C4b and C2a bind and make

A

c3 convertase of the classical pathway

26
Q

What triggers the leptin pathway?

A

mannose-binding lectin