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Flashcards in part 2 Deck (86):
1

inflammation

C3a

2

opsonization and phagocytosis

C3b

3

inflammation

C5a

4

MAC

lysis of microbe

5

second step in activation pathway?

production of c3b and formation of C3 convertase

6

What coes C3b initiates activation of?

C5 and formation of C 5 convertase

7

Last step

MAC, creates hole in plasma membrane

8

complement pathway

proteolytic cascades in which an inactive precursosr enzyme becomes active and cleaves next complement protein cascasde

9

complement system works in cooperation with/

blood coagulation pathways
kinin kallikrein system that regulates vascular permability

10

TLRs 1-9 bind?

microbial ags (LPS, peptidoglcans, viral mucleic acids)

11

expressed on cell surface of

TLR 1,2,4,5,6 DCs phagocytes B cells endothelial cells

12

expressed on endsosomal membrane

TLR3,7,8,9

13

NLRs location

cytosol of phagocytes, epithelial cells, and other cells,

14

PAMP/DAMP ligands of NLRs

bacterial cell wall peptidoglycans, intracellular crystals;

15

RLRs ligand

viral RNA

16

RLRs location

cytosol of phagocytes and other cells

17

CDS ligands

bacterial and viral DNA

18

WHat does tobacco smoke and pollutants activate?

TLR2 and TLR4

19

what are pamps?

molecular patterns on bacteria and viruses

20

TLR3

virus dsRNA

21

TLR7

birus ssRNA

22

TLR9

cystosine-phosphoyl guanine virus

23

TLR4

bacteria lipopolysaccharide

24

TLR2

bacteria peptiodglycans

25

TLR2, TLR6

lipoteiochoic acid bacteria

26

TLR5

flagellin bacteria

27

lipopolysaccaraides (LPS)

gram negative

28

lipoteichoic acid (LTA)

gram positive

29

DAMPs molecule patterns on endogenous intracellular proteints

-damage to cells by ROS
-HMGB1(nucleus to lysosome)
-S100 protein(cytoplasm)
-HSP exosomes
-extracellular matrix hyaluronans
-uric acid

30

What does capsase 1 activation cause?

release of inerlukin 1beta and 18 and can cause death of host cell

31

What are antimicrobial or anti inflammatory products?

defensisns
resolvins or protectins
eicosanoids that resolve inflamation

32

TLR1 and TLR2

bacterial lipopeptides

33

WHat adaptor do TLRs 1, 2,5, and 6 recognize/

MyD88

34

what does MyD88 activate?

NF-kB and AP-1

35

TLR 7 and 9 use MyD88 to activate?

NFkB and IRF7

36

What adaptor does TLR3 use?

TRIF and it activates IRF3 and IRF7 transcription factors

37

What do microbial lipoportines acvivate?

TLR2

38

What does LPS activate?

TLR4

39

WHat does bacterial DNA sequences contain unmethlated cytosine-guanosine dinucleoties (CpGs)

TLR9

40

What does the activation of NFkB result in?

transcription of pro inflammatory genes

41

WHat controls adaptive T cell immune response?

IL12

42

What does not signal through MyD88

TLR3, signals through TLR3

43

What engage TRIF and TRAM?

TLR4

44

What engage TIRAP and MyD88?

TLR4 and TLR2

45

WHat is produced in the inflammason

IL 1 beta and IL 18

46

WHat is a sub family of 14 NOD?

NLRP.... P is pyrin domain containing protein

47

What does NLRP responds to?

PAMPS and DAMPS by binding and forming singlaing complexes called inflammasomes

48

What does inflmmasome complexes activate?

caspase 1

49

What is the main function of caspase 1?

to cleave the inactive cytoplasmic precursor forms of two homologous cytokines 1 beta and 18

50

proinflammatroy cytokines

1 beta dn 18

51

what mediates the uptake of oxidized lipoproteins?

SRs

52

what SRs are expressed on Mo?

SR-A and CD36, recogniztion and phagocytosis of microorganims

53

What do SRs bind bacteria based on?

negative charges of bacterial LPS, lipoteichoic acid, nucleic acid....

54

WHat bind carbohydrates

C type lectin family

55

What do conserved carb recognition domain recognize?

microbial mannose, N acetylglucosamine, and betal glucans

56

eukaryotic carb cells are terminated by

galactos and sialic acid

57

lectin that are soluble protines are found in?

blood and extracellular fluids

58

Where are integral membrane proteins?

found on surface of macrophages and dendritic cells

59

What do mannose receptors recognize?

termal D mannose, Lfucose, and n acetyl D glucosamine sugsars on microbial surface

60

mannose receptor is involved in?

phagocytosis of microbes

61

what are small cationic peptiedes that contain both cationic anc hydrophobic regions?

defensins

62

what produce defensins?

epithleial cells of mucosal surface and nby granule containing leukocytes including,
neutorphils, NK, and CTLs

63

WHat stimulates the synthesis of defensins?

cytokines and microbial products

64

How do defensins kill?

inserting into and diruspting functions of the membrane

65

What produce cathelicidins?

neutorphils and barrier epithelial cells in the skin, gastorpintestinal tract and respiratory tract

66

What is cathelicinds cleaved into?

two protective peptides

67

What cleaves cathelicidins?

cytokines and microbial prodcuts

68

What is the C terminal fragment of cathelicidins called?

LL37, can bind and neutorpliez LPS

69

what play an anti inflammatory role aby binding to DNA and blocking AIM2 inflammasome acitvation

IL37

70

What transcription factor do innate lymphoid cells develop from?

Id2

71

Id2----> IL15 and IL7=

T bet

72

Id2--> IL7=

GATA3

73

Id2--> IL7=

RORgamma t

74

T bet, ILC1--> IL12, IL18=

IFN-gamma

75

defense against viruses

IFN gamma

76

gata3, ILC2--> IL25, IL33, TSLP

IL5, IL13

77

allergic response

IL5 and IL13

78

RORgammt, ILC3----> IL1 and IL23=

IL 17, IL22

79

intestinal barrier function; lymphoid organogenesis

il 17 and IL22

80

What response to IL12?

NK cells

81

WHat produces IL12

macrophages

82

CD16

IgG coated cell

83

NCRs(NKp46, NKp30, NKp44)

biral hemaglutinins, HLA-B transcript 3, B7-H6, heparin sulfate prtoegolycan (HSPG)

84

CD94

HLA-E

85

ILT2

HLAa, B, C, E,F G, CMB UL18

86

KIRs

HLA-C Bw4, A