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ANP 1107 > Lecture 12 > Flashcards

Lecture 12 Flashcards

1
Q

What are the 3 key players in adaptive immunity

A

B lymphocytes
T lymphocytes
Macrophages

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2
Q

What cells are associtaed with humoral immunity

A

B lymphocytes

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3
Q

What cells are associated with cell mediated immunity

A

T lymphocytes

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4
Q

What kind of leukocytes are the antigen presenting cells

A

Macrophages (monocytes)

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5
Q

B cells and T cells are what kind of leukocyte

A

Lymphocytes

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6
Q

Where do lymphocytes originate

A

Red blood marrow

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7
Q

Where do T cells mature

A

Thymus

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8
Q

Where do B cells mature

A

Bone marrow

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9
Q

Where do lymphocytes go once matured

A

Lymphoid organs
Circulation

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10
Q

What is positive selection

A

T cells need to pass the test on recognizing major histocompatibility complex

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11
Q

What is the name for the group of markers marking all nucleated cells as self

A

Major histocompatibility complex

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12
Q

Do T cells need to able to recognize the antigen during positive selection

A

Nope

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13
Q

What happens to T cells who cant recognize self MHC

A

Apoptosis

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14
Q

What occurs during negative selection

A

T cells must not recognize self antigens

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15
Q

What could happen if T cells recognize self antigens

A

Could cause autoimmune diseases

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16
Q

B cells cause what kind of immunity

A

Humoral

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17
Q

How long do plasma cells last

A

4-5 days

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18
Q

What is the effector B cell

A

plasma cells

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19
Q

What do plasma cells secrete

A

Antibodies

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20
Q

What are the two kinds of B cells

A

Plasma (effector)
Memory cells

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21
Q

How long do memory B cells last

A

Years

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22
Q

why do plasma cells have lots of RER

A

to make lots of antibodies

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23
Q

What is the first immunoglobulin secreted during primary response

24
Q

What immunoglobulin activates completement

A

IgM and IgG

25
What is the secretory immunoglobulin
IgA
26
What immunoglobulin is the dimer
IgA
27
What immunoglobulin is the pentamer
IgM
28
What immunoglobulin is found in body secretions
IgA
29
What immunoglobulin stops pathogens from attaching to epithelial cells
IgA
30
What immunoglobulin functions as a B cell antigen receptor
IgD
31
What is the most abundant immunoglobulin in the plasma
IgG
32
What is the main antibody of secondary and late primary responses
IgG
33
What immunoglobulin binds to mast cells or basophils
IgE
34
What immunoglobulin is involved in allergic reactions
IgE
35
What antibody crosses the placenta
IgG
36
What antibody is passed to a baby through milk
IgA
37
What is the only kind of immunity able to establish immunological memory
Active
38
What are the two ways to aquire Active and passive humoral immunity
Active: naturally: infection artificially: vaccine Passive: Naturally: antibodies passed through milk/placenta Artificially: injection of antibodies
39
Do antibodies kill cells
No, they just tag them
40
What are the 3 main types of T cells
CD8 CD4 Regulatory
41
What t cells are the killer t cells
Cytotoxic t cells CD8
42
What type of t cells are cytotoxic
CD8
43
What are the helper T cells
CD4
44
What type of t cells are CD4
Helper
45
CD8 t cells are what kind
cytotoxic
46
What do regulatory t cells do
winddown immune response
47
What type of t cells stop immune responses
Mainly regulatory, some CD4
48
What class of MHC molecules are recognized by CD8 t cells
I
49
What calls of MCH molecules are only recognized CD4 T cells
II
50
What type of cells have class II MHC
APCs
51
Where are monocytes formed
bone marrow
52
what is the major role of monocytes
engulf foreign particles and present fragments of their antigens on their surface to be recognized by T cells
53
What do monocytes secrete
soluble proteins that activate T cells
54
What do CD8 t cells release from its granules once binded to a target cell
perforin granzyme
55
What is the role of perforin and granzyme in CMI
perforin form holes in target cells granzymes enter the cell, and trigger apoptosis

ANP 1107 (21 decks)

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