Lecture 148 & 149 key concepts

Question 1

Majority are B cell but T cell may present as a mediastinal mass, especially in adolescent boys

Answer 1

Acute lymphoblastic leukemia

Question 2

DIC, Auer rods, All-Trans Retinoic Acid

Answer 2

Acute promyelocytic leukemia

Question 3

Prognosis of acute promyelocytic leukemia

Question 4

Philadelphia chromosome

Answer 4

Chronic myelogenous (myeloid) leukemia

Question 5

Monoclonal protein, M protein, plasmablasts, CRAB

Answer 5

Multiple myeloma

Question 6

CRAB mnemonic

Answer 6

Calcium increase, Renal dysfunctions, Anemia, Bone lesions

Question 7

Reed-Sternberg cells, EBV association, CD15 and CD30

Answer 7

Hodgkin lymphoma

Question 8

TdT

Answer 8

Lymphoblasts

Question 9

Esterase

Answer 9

Myeloblasts

Question 10

t(15;17)

Answer 10

Acute promyelocytic leukemia

Question 11

t(9;22)

Answer 11

Philadelphia chromosome CML

Question 12

t(8;14)

Answer 12

Burkitt lymphoma

Question 13

t(14;18)

Answer 13

Follicular lymphoma

Question 14

CD5, CD19, CD20, CD23

Answer 14

Chronic lymphocytic leukemia

Question 15

t(11;14)

Answer 15

Cyclin D-1 mantle cell lymphoma

Question 16

BCL-2, CD19, CD20, CD10

Answer 16

Bcl-2 follicular lymphoma

Question 17

“Starry sky”, high mitotic rate

Answer 17

Burkitts lymphoma

Question 18

White pulp spleen, paratrbecular bone marrow

Answer 18

Follicular lymphoma

Question 19

Skin involvement

Answer 19

Mycosis fungiodes/Sezary syndrome

Question 20

Rash

Answer 20

Adult T cell leukemia

Question 21

CLL/SLL transformation to more aggressive tumor like diffuse large B cell lymphoma

Answer 21

Richter syndrome

Question 22

CD19, CD20, BCL-6

Answer 22

Diffuse large B cell lymphoma

Question 23

EBV + mandible involvement

Answer 23

Endemic Burkitt

Question 24

Increased M protein

Answer 24

Multiple Myeloma

Question 25

Lytic lesions

Answer 25

Multiple myeloma

Question 26

Bence-Jones proteinuria

Answer 26

Multiple myeloma

Question 27

Extranodal marginal zone lymphoma

Answer 27

MALTomas

Question 28

CD4+ T cells infected by retrovirus HTVL-1

Answer 28

Adult T cell leukemia/lymphoma

Question 29

Clover leaf/flower tumor cells, hypercalcemia

Answer 29

Adult T cell leukemia/lymphoma

Question 30

CD4+ neoplastic T cells in skin, generalized exfoliative erythroderma

Answer 30

Sezary

Question 31

CD15+, CD30+, CD45-

Answer 31

Classical HL

Question 32

Collagen bands, lacunar variants of RS cells

Answer 32

Nodular sclerosing HL

Question 33

RS infected with EBV 70% of cases

Answer 33

Mixed cellularity HL

Question 34

Mononuclear RS cell variants, some EBV association

Answer 34

Lymphocyte rich HL

Question 35

EBV associated, elderly, HIV, less favorable diagnosis

Answer 35

Lymphocyte depletion

Question 36

L&H RS cells, CD20+, CD15-, CD30-

Answer 36

Lymphocyte predominance HL