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PPOM1 Block 4 > Lecture 186 > Flashcards

Lecture 186 Flashcards

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1
Q

What is associated with heliotrope rash and Grotton’s papules?

A

Dermatomyositis

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2
Q

What does CRASH & burn refer to?

A

Kawasaki disease

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3
Q

What are recurrent oral and genital lesions, uveitis indicative of?

A

Behcet’s disease

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4
Q

What condition presents with lung infiltrates and ‘apply jelly’ skin?

A

Sarcoidosis

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5
Q

What condition is associated with nose and GI bleed?

A

HHT/OWR

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6
Q

What are GI polyps and lip spots indicative of?

A

PJS

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7
Q

What condition is associated with multiple tumors and facial warts?

A

Cowden’s/MHS

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8
Q

What condition presents with a bumpy face and jaw, too many teeth, and GI polyps?

A

Gardner

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9
Q

What are skin tags associated with DM, obesity, and chronic GI polyps called?

A

Acrochordons

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10
Q

What condition presents with spider telangiectasias, palmar erythema, and terry nails?

A

Cirrhosis of the liver

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11
Q

What is indicated by a Sister Mary Joseph nodule?

A

Pancreatic cancer

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12
Q

What condition is associated with relapsing polychondritis and painful cartilage?

A

Cardiovascular disease

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13
Q

What symptoms are associated with chronic renal failure?

A

Anemia, xerosis, pruritis, uremic frost, calcification

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14
Q

What condition presents with pruritis and grouped papules/vesicles on extensors?

A

Dermatitis herpetiformis

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15
Q

What condition is characterized by edematous malnutrition with flag sign and enamel paint?

A

Kwashiorkor

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16
Q

What condition in a baby presents with zinc deficiency, vesiculobullous and erythematous rash, diarrhea, alopecia, and frequent infections?

A

Acrodermatitis enteropathica

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17
Q

What are the 3 D’s of niacin deficiency/pellagra?

A

Dermatitis (Casal’s necklace), diarrhea, dementia

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18
Q

What symptoms are associated with scurvy?

A

Follicular hyperkeratotic plaques, corkscrew hairs, gingivitis, anemia

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19
Q

What can anti-dsDNA autoantibodies in SLE indicate?

A

Kidney and skin disease

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20
Q

What can anti-Smith autoantibodies in SLE indicate?

A

Kidney disease

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21
Q

What can anti-Ro/SS-A autoantibodies in SLE indicate?

A

Skin and kidney disease, fetal heart problem

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22
Q

What can anti-histone autoantibodies in SLE indicate?

A

Drug induced lupus

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23
Q

What ‘HIP’ drugs most commonly cause drug induced lupus?

A

Hydralazine, isoniazid, and procainamide

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24
Q

What can anti-phospholipid autoantibodies in SLE indicate?

A

Thrombosis, pregnancy loss

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25
What autoantibodies are positive in >80% of subacute cutaneous LE?
Anti-Ro (SS-A)
26
What describes discoid chronic cutaneous LE?
Scarring alopecia, sharply defined, erythematous scale, follicular plugging, scarring, carpet tack spines on undersurface of scales
27
What systemic disease is associated with anti-Jo-1 autoantibodies?
Dermatomyositis
28
What type of malignancy is a concern in women with dermatomyositis?
Ovarian cancer
29
What physical testing should be done on women diagnosed with dermatomyositis?
Pap smear, breast exam, CXR, stool test
30
What physical testing should be done on men diagnosed with dermatomyositis?
Rectal exam, CXR, stool test
31
What labs should be performed for evaluation of dermatomyositis?
Creatine phosphokinase and antibody studies (anti-Jo-1)
32
What condition involves fibroblasts overproducing collagen, leading to fibrosis and sclerotic changes?
Scleroderma
33
What type of scleroderma presents with violaceous to ivory hardened skin, with possible underlying atrophy?
Localized- morphea
34
What does 'en coup de sabre' localized scleroderma present as?
Linear morphea of the head
35
Acrosclerosis is limited to which areas?
Hands, feet, face, and arms
36
Acrosclerosis (limited type) belongs to what subset of scleroderma?
Systemic scleroderma
37
What does CREST stand for?
Calcium deposits, Raynaud's, Esophageal dysfunction, Sclerodactyly, Telangiectasias
38
What systemic disease is associated with CREST?
Scleroderma
39
What type of scleroderma presents initially with Raynaud's and progresses to pulmonary fibrosis?
Progressive type (PSS)
40
What tests should be used to diagnose scleroderma?
ANA, anti-Scl70, and anti-centromere autoantibody tests
41
What is sarcoidosis?
Systemic granulomatous disease of unknown etiology, primarily affecting the lungs
42
Sarcoidosis is more common in which demographic?
Black patients
43
What does it mean if a lesion is diascopy positive?
Blanching with a glass slide reveals 'apply-jelly' color
44
What systemic disease is characterized by lupus pernio, diascopy positive lesions, non-caseating granulomas, and hypercalcemia?
Sarcoidosis
45
What does erythema nodosum indicate in sarcoidosis?
Best prognosis
46
What condition is characterized by recurrent oral aphthous ulcers, genital aphthous, and uveitis?
Behcet's disease
47
What does a positive pathergy test indicate?
Behcet's disease
48
What does CRASH in Kawasaki disease stand for?
Conjunctival, Rash (palms/soles to trunk spread), Adenopathy, Strawberry tongue, Hand/foot edema
49
What type of GVHD is indicated by maculopapular rash and SJS/TEN?
Acute
50
What type of GVHD is indicated by skin sclerosis, cellulite-like plaques, and poikiloderma?
Chronic
51
What is Osler-Weber-Rendu syndrome also known as?
Hereditary hemorrhagic telangiectasia (HHT)
52
What are the symptoms of hereditary hemorrhagic telangiectasia (HHT)?
Telangiectasias of the mouth and GI tract, epistaxis in childhood, melena
53
What condition is characterized by >100 adenomatous colorectal polyposis, epidermal cysts, osteomas, and supernumerary teeth?
Gardner syndrome
54
What condition is associated with multiple hamartomatous GI polyps and spotty melanin pigmentations?
Peutz-Jeghers syndrome
55
What types of cancer can Peutz-Jeghers syndrome increase the risk of?
GI
56
What is Cowden's syndrome also known as?
Multiple hamartoma syndrome
57
What are the characteristics of Cowden's syndrome?
GI polyps, warty papules, multiple hamartomatous tumors, increased risk of malignancy
58
What sign indicates that the proximal 2/3rd of the nail plate appears white?
Terry nails; liver disease
59
What is a malignant metastatic umbilical nodule called?
Sister Mary Joseph's nodule
60
How does the prognosis of pancreatic cancer change in the presence of a Sister Mary Joseph nodule?
Poor prognosis
61
What condition is characterized by recurrent tender, erythematous, warm, swollen ear?
Relapsing polychondritis (RPC)
62
What skin sign may be associated with heart-aortic insufficiency and aortic aneurysms?
Relapsing polychondritis
63
What are the symptoms of Kwashiorkor?
Peripheral pitting edema, 'enamel paint' dermatoses, and flag signs
64
What mineral is deficient in acrodermatitis enteropathica?
Zinc
65
What condition is closely related to dermatitis herpetiformis?
Celiac disease/gluten sensitivity
66
What does a skin biopsy showing granular IgA deposits at the tips of dermal papillae indicate?
Dermatitis herpetiformis
67
Where are cutaneous findings of dermatitis herpetiformis commonly found?
Extensor (elbows, forearms, knees, scalp, or buttocks)

PPOM1 Block 4 (44 decks)

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