Lecture 150

Question 1

What type of T cells are lymph node/bone marrow homing and have rapid proliferation on re-exposure?

Answer 1

Central memory T cells (TCM)

Question 2

What type of T cells circulate in blood & non-lympphoid tissues for immediate defense?

Answer 2

Effector memory T cells (TEM)

Question 3

What type of T cells are permanently “staioned” in epithelia and are first responders to mucosal pathogens?

Answer 3

Resident memory T cells (TRM)

Question 4

What is the mechanism of the live-attenuated influenza vaccine (LAIV)?

Answer 4

Stimulates mucosal IgA and cell-mediated immunity resembling natural infection

Question 5

Which polio vaccine is inactivated?

Answer 5

IPV (Salk)

Question 6

Which polio vaccine in used in the US?

Answer 6

IPV (Salk)

Question 7

The IPV (Salk) vaccine induces which immunoglobulin?

Answer 7

Systemic IgG

Question 8

The IPV vaccine prevents paralysis but has what limitation?

Answer 8

Does not prevent gut replication

Question 9

Which polio vaccine is live-attenuated?

Answer 9

OPV (Sabin)

Question 10

The OPV (Sabin) vaccine induces which immunoglobulin?

Answer 10

Muscosal IgA

Question 11

What are the risks of the OPV vaccine?

Answer 11

Vaccine-associated paralytic polio (VAPP) & circulating vaccine-derived poliovirus (cVDPV)

Question 12

What does cGMP stand for in context of vaccines?

Answer 12

Current Good Manufacturing Practice (cGMP)

Question 13

What are the three determinants of vaccine acceptance?

Answer 13

Confidence, complacency, convenience