mid 2 review

Question 1

how does compliment kill

Answer 1

opsonization and anaphalatoxins

Question 2

where are complient proteins

Answer 2

circulating and membrane bound

Question 3

what are compliment proteins made by

Answer 3

liver hepatocytes
tissue macrophages
blood monocytes
epithelial cells

Question 4

the two heads of c1q must bind to what

Answer 4

one igm - planar and staple form exposes CH2

or two close igGs (IgG3)

Question 5

what does MBL have

Answer 5

two protesases
MASP 1 and 2 that activate when bound to terminal mannose residues

Question 6

MBL and C1q

Answer 6

structurally homologous

Question 7

steps of alternate pathway

Answer 7

C3b spontaneously produces
factor B binds
factor d cleaves to c3bBb
this normally dissocaites but stabilized by properdin (factor P)
now it cleaves more C3 (positive feedback loop)

Question 8

what are the way so of regulating complement

Answer 8

C1 dissociation
DAF- decay accelerating factor of C3 convertases in lectin and classical
factor I cofactor- breaks up C3b and C4b
protectin- inhibitsMAC and poly C9
breaknig down anaphalatoxins by carboxypeptidase

Question 9

what are the functions of compliment

Answer 9

removal of ag:ab complexes: RBCs bind complement

activate B cell signalling by activating compleemnt receptors

removal of necrotic and subsceullular memnrane

response to virus by all 3 types of compliment

Question 10

at the _ level, HLA = MHC

Answer 10

protein

Question 11

at the _ level HLA = H2

Answer 11

DNA

Question 12

how many classes of MHC are ther =e

Answer 12

3

Question 13

a and b chain of MHC I

Answer 13

a is HLA-A, HLA-B, HLA-C and B2 microglobulin chain that is invariant and coded by a non MHC gene

Question 14

a and b chain of MHC II

Answer 14

a in HLA-DR is non polymorphic

a and b in HLA-DP and HLA-DQ is polymorphic

Question 15

what occurs w the MHC receptor genes

Answer 15

no gene rearrangement

Question 16

what MHC expressed on all cells

Answer 16

MHC I

Question 17

how can MHC II be expressed on cells its not supposed to

Answer 17

it can deputize cells that arent pAPC by IFN Y

Question 18

polygenic

Answer 18

many genes in the complex

Question 19

polymorphic

Answer 19

many alleles that can make up the gene q

Question 20

what MHC are anchor residues in

Answer 20

MHC I on the ends at 2 and 9
H bonding
less variability
shorter peptides

Question 21

MHC II conserved residues

Answer 21

througout the peptide

Question 22

what MHC is endogenous peptides

Answer 22

MHC I

Question 23

process of MHC I antigen and receptor

Answer 23

peptide is into proteosome and TAP1/2 brings it into the ER

using ATP

Question 24

process of MHC II antigen and recepto

Answer 24

a and b chain made in ER
assocaite w invariant li or CD74 that goes into the golgi and becomes CLIP and then peptide is endoctosed and associates w acidic protease vesicles that degrade it and HLA-DM catalyzes its switch w CLIP

Question 25

what MHC leads to cytokine and inflamation

Answer 25

MHC II

Question 26

what MHC leads to perforins and granzyme release

Answer 26

MHC I

Question 27

what is cross presentation

Answer 27

dendrictic cells TRANSFER exogenous antigens on MHC I to activate Th cells

Question 28

what MHC allele makes it more likely to deveop ankylosing spondylitis

Answer 28

HLA-B27

Question 29

what MHC allele makes it more likely to not respond to hep B vaccine

Answer 29

HLA-DR3

Question 30

what animal has limited polymorphism in their MHC genes

Answer 30

cheetas

Question 31

tasmanian devils

Answer 31

transmit cancer through bites
have no MHC I activity
no NK cell activity