review 2

Question 1

genetic component of RA

Answer 1

HLA DR4

Question 2

RA immune complexes and what cells involved

Answer 2

igM against Fc of igG

autoreactive CD4 TH1 cells

CD4 TH17 Cytokines IFNY and IL17

macro[hages and fibroblasts have feedforward mech

Question 3

RA symptoms

Answer 3

chronic inflamation and erosion of synovium and bone

Question 4

what cells in T1D

Answer 4

CD8+
TH1
cytokines
CD4 MHC II innaprooperiate expression
destruction of insuling B ilset cells of pancrease leads to autoantibody formation

Question 5

genetic component of T1D

Answer 5

HLA DQ 2 and 8 and and some non HLA genes

Question 6

genetic component of MS

Answer 6

HLA II DR 15 DQ6

Question 7

what mediates MS

Answer 7

T cells infiltrate the brain and cause inflammatory lesions that destroy myelin sheath due to sequested release of myelin ags or molecular mimmickery following EBV infection

Question 8

what cells in MS

Answer 8

autoreactive TH1 cells activate macrophages, inflammation, inc macrophage, neutrophil, mast cell, Fas mediated cell death of oligodendrocytes

Question 9

hashimotos thyroditis populatoin

Answer 9

middle aged women

Question 10

hashimotos cells

Answer 10

autoantibodies against microsomal and thyroglobulin

sensitized TH1 for thyroid antigen

intense infiltration of thyroid gland by mononuclear cells that interfere w iodine uptake and dec production of thyroid hormones

Question 11

result of hashimotos

Answer 11

hypothyroidism and goiter formation

Question 12

symptoms of SLE

Answer 12

butterfly rash due to anti DNA abs and formation of immune complexes (III) that deposit in the kidney and cause inflamation

Question 13

SLE population

Answer 13

women 10:1 men

worsened during pregnancyg

Question 14

genetic component of SLE

Answer 14

HLA association