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Flashcards in Neoplasia Deck (73):
1

BRC-ABL

CML, ALL
(GOF in tryosine kinase)

2

bcl-2

Follicular and undifferentiated lymphomas
(GOF in anti-apoptotic molecule)

3

BRAF

Melanoma
(GOF in serine/threonine kinase)

4

c-kit

GIST
(GOF in cytokine receptor for stem cell factor)

5

c-myc

Burkitt lymphoma
(GOF in transcription factor)

6

HER2/neu (c-erbB2)

Breast, ovarian, gastric carcinomas
(GOF in tyrosine kinase)

7

L-myc

Lung tumor
(GOF in transcription factor)

8

N-myc

Neuroblastoma
(GOF in transcription factor)

9

ras

Colon, lung and pancreatic cancer
(GOF in GTPase)

10

ret

MEN 2A and 2B
(GOF in tyrosine kinase)

11

APC

Colorectal cancer (FAP)
(LOF)

12

BRCA1 and BRCA2

Breast and Ovarian
(LOF in DNA Repair protein)

13

CPD4/SMAD4

Pancreatic cancer
(DPC= deleted in pancreatic cancer)

14

DCC

Colon Cancer
(DCC= deleted in colon cancer)

15

MEN1

MEN type 1
(LOF)

16

NF1

Neurofibromatosis type 1
(LOF in RAS GTPase activating protein (neurofibromin))

17

NF2

Neurofibromatosis type 2
(LOF in Merlin (schwannomin) protein)

18

p16

Melanoma
(LOF in cyclin-dependent kinase inhibitor 2A)

19

p53

Most cancer (Li-Fraumeni syndrome)
(LOF in TF for p21 to prevent block of G1 to S)

20

PTEN

Breast, prostate, endometrial cancer
(LOF)

21

Rb

Retinoblastoma, osteosarcoma
(LOF in inhibitor of E2F (can't block G1 to S))

22

TSC1

Tuberous sclerosis
(LOF in hamartin protein)

23

TSC2

Tuberous sclerosis
(LOF of Tuberin protein)

24

VHL

von Hippel-Lindau disease
(LOF in HIF1a)

25

WT1 and WT2

Wilms Tumor (nephroblastoma)

26

What is alkaline phosphate a marker for?

-Mets to bone and liver
-Paget disease of bone
-Seminoma (placental ALP)

27

What is alpha-fetoprotein a marker for?

-HCC
-Hepatoblastoma
-Yolk sac (endodermal sinus) tumor
-Testicular cancer
-Mixed germ cell tumor (secreted with beta-hCG)

28

What is beta-hCG a marker for?

-Hydatidiform moles and Choriocarcinomas (gestational trophoblastic disease)
-Testicular cancer
-Pregnancy

29

What is CA-15-3/CA-27-29 a marker for?

Breast cancer

30

What is CA-19-9 a marker for?

Pancreatic adenocarcinoma

31

What is CA-125 a marker for?

Ovarian cancer

32

What is calcitonin a marker for?

Medullary thyroid carcinoma

33

What is CEA (carcinoembryonic antigen) a marker for?

-Nonspecific for 70% colorectal and pancreatic cancers
-Also produced by gastric, breast and medullary thyroid carcinomas

34

What is PSA a marker for?

-Used to follow prostate adenocarcinoma
-Can be elevated in BPH and prostatitis

35

What is S-100 a marker for?

-Neural crest origin (melanomas, neural tumors, schwannomas, Langerhans cell histiocytosis)

36

What is TRAP (tartrate-resistant acid phsophatase) a marker for?

-Hairy cell leukemia (B-cell neoplasm)

37

EBV associated cancer.

Burkitt lymphoma
Hodgkin lymphoma
Nasopharyngeal carcinoma
CNS lymphoma

38

HBV/HCV associated cancer.

HCC

39

HHV-8 associated cancer.

-Kaposi sarcoma
-Body cavity fluid B-cell lymphoma

40

HPV (16, 18) associated cancer.

-Cervical and penile/anal carcinoma
-Head & Neck or throat cancer

41

H. pylori associated cancer

-Gastric adenocarcinoma
-MALT lymphoma

42

HTLV-1 associated cancer.

-Adult T-cell leukemia/lymphoma

43

Liver fluke (Clonorchis sinensis) associated cancer.

Cholangiocarinoma

44

Schistosoma haematobium associated cancer.

Bladder cancer (squamous cell)

45

Aspergillus aflatoxins associated cancer

HCC

46

Alkylating agent associated cancer

Leukemia/lymphoma

47

Aromatic amines (benzidine, 2-naphthylamine) associated cancer

Transitional cell bladder carcinoma

48

Arsenic associated cancer

-Angiosarcoma (liver)
-Lung cancer
-Squamous cell skin cancer

49

Asbestos associated cancer

Bronchogenic carcinoma --> mesothelioma

50

Carbon tetrachloride associated cancer

Centrilobular necrosis; fatty chancer

51

Cigarette smoke associated cancer

-Transitional cell carcinoma of bladder
-Squamous cell carcinoma/adenocarcinoma of esophagus
-RCC
-Squamous cell carcinoma of larynx
-Squamous/Small cell carcinoma of lung
-Pancreatic adenocarcinoma

52

Ethanol associated cancer

HCC

53

Ionizing radiation associated cancer

Papillary thyroid carcinoma

54

Nitrosamines (smoked foods) associated cancer

Gastric cancer

55

Radon associated cancer

Lung cancer (2nd leading cause after cigarettes)

56

Vinyl chloride associated cancer

Angiosarcoma of liver

57

Cancer with hypercalcemia from increased calcitriol

-Hodgkin lymphoma
-some non-Hodgkin lymphomas

58

Cancer with Cushing syndrome fro increased ACTH

Small cell lung cancer

59

Cancer with SIADH

-Small cell lung carcinoma
-Intracranial neoplasms

60

Cancer with Lambert-Eaton myasthenic syndrome (due to Ab against pre-synaptic Ca2+ channels at NMJ)

Small cell lung carcinoma

61

Cancers with polycythemia

-RCC
-Hemangioblastoma
-HCC
-Leiomyoma
-Pheochromocytoma

62

Cancers with Hypercalcemia from PTHrP release

-Squamous cell lung cancer
-RCC
-Breast cancer

63

Cancers with pasmmoma bodies

-Papillary carcinoma of thyroid
-Serous papillary cystadenocarcinoma of ovary
-Meningioma
-Malignant mesothelioma

64

Carcinomas that spread hematogenously

-RCC (renal vein)
-HCC (hepatic vein)
-Follicular carcinoma of thyroid
-Choriocarcinoma

65

Brain mets usually from what places?

Lung> breast > GU

66

Liver mets usually from what places?

Colon>> stomach > pancreas

67

Bone mets usually from what places?

Prostate, breast > lung > thyroid

68

Blastic bone mets from where?

PROSTATE
(breast is lytic and blastic)

69

Acanthosis nigricans associated cancer

Visceral (stomach) malignancy

70

Actinic keratosis associated cancer

Squamous cell carcinoma (skin)

71

Dermatomyositis associated cancer

Lun cancer

72

Myasthenia gravis associated cancer

Thymoma

73

Tuberous sclerosis associated cancer

Giant cell astrocytoma
Renal angiomyolipoma
Cardiac rhabdomyoma