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1st Aid Memorize > GPCR > Flashcards

Flashcards in GPCR Deck (32)
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1
Q

List All Gq

A

“Q can HAVe 1 M&M”

H1, Alpha1, V1, M1, M3

2
Q

List all Gi

A

“MAD 2s”

M2, Alpha2, D2

3
Q

List all Gs

A

Beta1, Beta2, D1, H2, V2

4
Q

Receptor that:

  • Increases SM contraction
  • Increases pupillary dilator contraction
  • Increase intestinal and bladder sphincter muscle contraction
A

Alpha1

5
Q

Receptor that:

  • Decreases HR
  • Decreases contractility of atria
A

M2

6
Q

Receptor that:

  • Increases nasal and bronchial mucus production
  • Increases vascular permeability
  • Contracts bronchioles
  • Causes pruritis/pain
A

H1

7
Q

Receptor that:

-Increases H2O permeability and reabsorption in collecting tubules of kidney

A

V2 (found in 2 kidneys)

8
Q

Receptor that causes:

  • Vasodilation
  • Bronchodilation
  • Increased HR
  • Increased contractility
  • Increased lipolysis
  • Increased insulin release
  • Decreased uterine tone (tocolysis)
  • Ciliary muscle relaxation
  • Increased aqueous humor production
A

Beta-2

9
Q

Receptor that causes:

  • Decreased sympathetic outflow
  • Decreased insulin release
  • Decreased lipolysis
  • Increased platelet aggregation
A

Alpha-2

10
Q

Receptor that causes:

  • Increased exocrine gland secretions (ex. lacrimal, salivary, gastric acid)
  • Increased gut peristalsis
  • Increased bladder contraction
  • Bronchoconstriction
  • Increased pupillary sphincter contraction (miosis)
  • Ciliary muscle contraction (accommodation)
A

M3

11
Q

Receptor that causes:

-Relaxed renal vascular SM

A

D1

12
Q

Receptor that causes:

-Increased vascular SM contraction

A

V1

13
Q

Receptor that modulates transmitter release (especially in brain)

A

D2

14
Q

Receptor that:

  • Increases HR
  • Increases contractility
  • Increases Renin release
  • Increases lipolysis
A

Beta-1

15
Q

Receptor that works in CNS and enteric nervous system

A

M1

16
Q

Receptor that increases gastric acid secretion

A

H2

17
Q

Epinephrine specificity

A

Beta > alpha

18
Q

Norephinephrine specificity

A

Alpha1 > Alpha2 > Beta1

19
Q

Isoproterenol specificity

A

Beta1 = Beta2

20
Q

Dopamine specificity

A

D1 = D2 > Beta > alpha

21
Q

Dobutamine specificity

A

Beta1 > Beta2 > alpha

22
Q

Phenylephrine specificity

A

Alpha1 > Alpha2

23
Q

Albuterol and terbutaline specificity

A

Beta 2 > Beta 1

24
Q

Clonidine and Alpha-Methyldopa

A

Alpha2 agonist

25
Q

Phenoxybenzamine

A

Irreversible, nonselective alpha blocker

26
Q

Phentolamine

A

Reverxible, nonselective alpha blocker

27
Q

Acebutolol, Metrolol

A

Beta 1 > Beta 2

28
Q

Prazosin, Tamsulosin

A

Alpha1 selective blocker

29
Q

Carvedilol, labetalol

A

Nonselective alpha and beta blocker

30
Q

Mirtazapine

A

Alpha2 selective blocker

31
Q

Nadolol, Propranolol

A

Beta1 = Beta2 blocker

32
Q

Nebivolol

A

Beta1 block with stimulation of Beta3