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1st Aid Memorize > GPCR > Flashcards

Flashcards in GPCR Deck (32):
1

List All Gq

"Q can HAVe 1 M&M"
H1, Alpha1, V1, M1, M3

2

List all Gi

"MAD 2s"
M2, Alpha2, D2

3

List all Gs

Beta1, Beta2, D1, H2, V2

4

Receptor that:
-Increases SM contraction
-Increases pupillary dilator contraction
-Increase intestinal and bladder sphincter muscle contraction

Alpha1

5

Receptor that:
-Decreases HR
-Decreases contractility of atria

M2

6

Receptor that:
-Increases nasal and bronchial mucus production
-Increases vascular permeability
-Contracts bronchioles
-Causes pruritis/pain

H1

7

Receptor that:
-Increases H2O permeability and reabsorption in collecting tubules of kidney

V2 (found in 2 kidneys)

8

Receptor that causes:
-Vasodilation
-Bronchodilation
-Increased HR
-Increased contractility
-Increased lipolysis
-Increased insulin release
-Decreased uterine tone (tocolysis)
-Ciliary muscle relaxation
-Increased aqueous humor production

Beta-2

9

Receptor that causes:
-Decreased sympathetic outflow
-Decreased insulin release
-Decreased lipolysis
-Increased platelet aggregation

Alpha-2

10

Receptor that causes:
-Increased exocrine gland secretions (ex. lacrimal, salivary, gastric acid)
-Increased gut peristalsis
-Increased bladder contraction
-Bronchoconstriction
-Increased pupillary sphincter contraction (miosis)
-Ciliary muscle contraction (accommodation)

M3

11

Receptor that causes:
-Relaxed renal vascular SM

D1

12

Receptor that causes:
-Increased vascular SM contraction

V1

13

Receptor that modulates transmitter release (especially in brain)

D2

14

Receptor that:
-Increases HR
-Increases contractility
-Increases Renin release
-Increases lipolysis

Beta-1

15

Receptor that works in CNS and enteric nervous system

M1

16

Receptor that increases gastric acid secretion

H2

17

Epinephrine specificity

Beta > alpha

18

Norephinephrine specificity

Alpha1 > Alpha2 > Beta1

19

Isoproterenol specificity

Beta1 = Beta2

20

Dopamine specificity

D1 = D2 > Beta > alpha

21

Dobutamine specificity

Beta1 > Beta2 > alpha

22

Phenylephrine specificity

Alpha1 > Alpha2

23

Albuterol and terbutaline specificity

Beta 2 > Beta 1

24

Clonidine and Alpha-Methyldopa

Alpha2 agonist

25

Phenoxybenzamine

Irreversible, nonselective alpha blocker

26

Phentolamine

Reverxible, nonselective alpha blocker

27

Acebutolol, Metrolol

Beta 1 > Beta 2

28

Prazosin, Tamsulosin

Alpha1 selective blocker

29

Carvedilol, labetalol

Nonselective alpha and beta blocker

30

Mirtazapine

Alpha2 selective blocker

31

Nadolol, Propranolol

Beta1 = Beta2 blocker

32

Nebivolol

Beta1 block with stimulation of Beta3