Pharmacology 1 Flashcards Preview

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Flashcards in Pharmacology 1 Deck (7)
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1
Q

Define receptors.

A

Enable specify and mean that the response evoked is also specific.

2
Q

Define steroid hormones.

A

Lipid soluble and bind to intracellular receptors to alter the rate of transcription.

3
Q

What does NO do with intracellular receptors?

A

It binds to soluble guanylyl cyclase and generates cGMP as as 2nd messenger which regulates cell activity.

4
Q

What are the 4 types of plasma membrane receptors and their functions?

A

Ion channels - Ionotropic receptors -> Fast EPSPs/IPSPs
Intrinsic enzyme activity - receptor tyrosine kinases -> proliferation or differentiation
JAK kinases - -> protein synthesis
G-proteins - Biggest group with several sub families.

5
Q

Define G-proteins.

A

Made up of 3 subunits and when activated the alpha g-protein subunit goes and regulates activity. It is one big amino acid chain with 7 hydrophobic loops.

6
Q

Name 3 G-Protein Coupled Receptors

A

Adenylyl Cyclase - activates/inhibits PKA
Phospholipase C - produces diacylglycerol
Ion channels - Evoke slow EPSPs/IPSPs

7
Q

Where can calcium be sourced from to be a 2nd messenger?

A

Internal stores
Voltage/ligand gated channels
Inhibition of calcium channels