Test 1 chapter 11 Flashcards Preview

Patho > Test 1 chapter 11 > Flashcards

Flashcards in Test 1 chapter 11 Deck (17)
Loading flashcards...
1

3 stages of the GAS syndrome

Alarm
Resistance/Adaption
Exhaustion

2

stressor triggers hypothalmic-pituitary adrenal axis
Activates sympathetic nervous system

Alarm stage

3

mobilization to flight/flee/freeze
Adrenal hormones actions of cortisol, epinephrine and norepinephrine

resistance/Adaptation

4

if stress continues and adaption unsuccessful then progressive breakdown of compensatory mechanisms will happen and cause disease on set and impaired immune response and cardiac and renal failure and then death

exhaustion stage

5

catecholamines (epinephrine and norepinephrine) short acting
Energy for self-preservation

stress SAM axis

6

corticosteroids (cortisol) long acting, sustained
Perception of stress

stress HPA axis

7

circulate bound to albumin

catecholamines

8

catecholamine that is widespread, short action due to repaid metabolism

epinephrin

9

regulates blood pressure by constricting smooth meuscle in all blood vessels
During stress it reissues blood pressure by constricting peripheral vessels, it dilates the pupils, cause piloerrection, and increases sweet gland action in the armpits and palms

norepinephrine

10

causes transient hyperglycemia, decrease glucose uptake in the muscle and other organs and decreases insulin release from the pancreas

epinephrin

11

Epinephrin cardiac effects

increase myocardial contractility
Increases heart rate
Increase venous return to the heart

12

epinephrin binds to what receptors

Alpha and beta adrenergic receptors

13

norepinephrine binds to what receptors

alpha adrenergic receptors

14

epinephrine metabolic effects

Dilates skeletal muscle vessels which increases O2
Transient hyperglycemia
Decreases glucose uptake and insulin release
Mobilizes free fatty acids and cholesterol by stimulating lipolysis

15

adaptive physiological response to stress

allostasis

16

cumulative stress, individualized, "wear and tear" and lead to disease

Allostatic load

17

Exaggerated pathophysiological response to stress
Increases Catecholamines, cort, proinflamitorry cytokines
Decreases PNS activity

allostatic overload