Graves Disease L11 Flashcards
1
Q
What is graves disease
A
Graves disease is a common cause of hyperthyroidism (over production of thyroid hormone). Its caused by stimulation of the thyroid by thyroid stimulating hormone (TSH) receptor by auto antibodies
– so type II mediated hypersensitivity, but also classified as type V as the autoantibodies bind to receptors
2
Q
What is exophthalmos
A
Due to an immune response where a TSH receptor is induced by autoantibodies, which cause orbital connective tissue to proliferate and enlarge, pushing the eye forward and putting force on the optic nerve
3
Q
Symptoms of graves disease
A
It is associated with enlargement of the thyroid, exophthalmos, heat intolerance and anxiety
