ANTICOAGULANT, ANTIPLATELET AND THROMBOLYTICS

Question 1

• formation of a clot in an arterial or venous vessel

Answer 1

Thrombosis

Question 2

Drugs that Suppress Thrombosis

Answer 2

1. Oral and parenteral anticoagulants (warfarin and heparin) - prevent venous
   thrombosis,
2. Antiplatelet drugs - prevent arterial thrombosis

Question 3

antidote to heparin overdose

Answer 3

Protamine sulfate

Question 3

For vitamin K deficiency,
antidote for warfarin overdose

Answer 3

Phytonadione

Question 3

Warfarin

Answer 3

For DVT and PE prophylaxis
and treatment, prophylaxis of
thrombosis, and unstable
angina; unstable angina and
for prophylaxis, safe for
pregnant women

Question 4

PT ( Prothrombin time) will be

Answer 4

1.25-2.5 times the control level, or INR will be 2-3

Question 5

ANTIPLATELETS

Answer 5

-prevent thrombosis in the arteries by suppressing platelet aggregation.
-acts by decreasing the responsiveness of platelets to stimuli causing it to clump or aggregate.
–formation of platelet plugs is decreased.

Question 6

ANTIPLATELETS

Cilostazol

Answer 6

-inhibit platelet aggregation
-vasodilator for intermittent claudication, PVD

Question 6

ANTIPLATELETS

Aspirin

Answer 6

suppress platelet aggregation
-prevention, treatment for stroke, prophylaxis of MI, tromboembolism
-has prolonged antiplatelet activity, discontinue at least 7 days before surgery
S/E: bleeding, GI distress, Reye syndrome

Question 6

ANTIPLATELETS

Clopidogrel

Answer 6

-frequently used after MI or stroke to prevent second event
-prevent thrombosis associated with unstable angina, MI, stroke, TIA

Question 7

THROMBOLYTICS

Answer 7

Promote fibrinolytic mechanism
● Attacks and dissolves blood clots
● Administered as soon as possible
● Should be administered within 3 hours of a thrombolic stroke\

Question 8

THROMBOLYTICS
drug

Answer 8

Alteplas
e

To promote fibrinolysis associated with thrombosis, AMI,
PE, ischemic stroke, occluded IV catheter