Antiulcer Drugs Flashcards
(14 cards)
Peptic Ulcer
– a sore on the lining of the stomach or within the upper gastrointestinal (GI)
tract.
Helicobacter pylori
– a gram-negative bacillus, linked with the development of peptic ulcer
and is known to cause gastritis, gastric ulcer, and duodenal ulcer
can detect H. Pylor
noninvasive breath test - urea breath test
Types of Ulcers
Esophageal UlceR
occurs in the lower part of the esophagus.
- result of a defective or incompetent cardiac sphincte
Types of Ulcers
Gastric Ulcer
– in the stomach.
- occurs because of breakdown of GMB
Types of Ulcers
Duodenal Ulce
– develops in the first part of the small intestine(duodenum).
Causes:
- insufficient buffers to neutralize gastric acid in the stomach
- a defective or incompetent pyloric sphincter
- hypermotility of the stomach
Tranquilizers
Diazepam
action
decrease vagal activity
Gastric Mucosal Barrier (GMB)
thick, viscous, mucuos material that maintains the integrity
of the gastric mucosal lining; a defense against corrosive substances.
Gastroesphageal reflux disease (GERD
– “heartburn” or pyrosis inflammation or erosion of
esophageal mucos
Antacids
neutralize gastric acid
Hydroxide
Aluminum Hydroxide
magnesium Hydroxide
H2 blockers
● Cimetidine
● Ranitidine
● Famotidine
block the H2 receptor =
acid production
Proton-pump inhibitors
(PPIs)
inhibit gastric acid
secretion, regardless of
acetylcholine or
histamine release.
● agents block the final
step of acid production
and are used to treat
peptic ulcers and gerd
Pepsin inhibitor
sucralfate (Mucosal
Protective Drugs
inhibits peptic activity by
both adsorbing pepsin
and buffering hydrogen
ions
Prostaglandin E1
analogue misoprostol
inhibits gastric acid secretion
and protects the mucosa
Misoprostol is
contraindicated during
pregnancy and for women of
childbearing age
