TARGETED THERAPIES FOR CANCER Reporters 18

Question 1

Angiogenesis inhibitors

Answer 1

• blocks the growth of blood vessels so cancer cells won’t get their
  supply of nutrients. Others go after different substances that trigger blood vessel growth.

Question 2

Small-molecule drug

Answer 2

• blocks cancer cells from multiplying and spreading by targeting cells
  on the inside because of its small size, making it easy to enter cells; inhibits enzymes and
  formation of new vasculatures, induces apoptosis.

Question 3

Vascular Endothelial Growth Factor/Receptor Inhibitors-

Answer 3

agents that inhibit the activity of
VEGF and VEGFR.

Question 4

ANGIOGENESIS INHIBITORS/RECEPTOR INHIBITORS

Answer 4

Bevacizumab

Question 5

ANGIOGENESIS INHIBITORS/RECEPTOR INHIBITORS

Bevacizumab

Answer 5

Indicated for management of cervical, colorectal, and ovarian cancers;
metastatic RCC; non-small cell lung cancer (NSCLC); and relapsed
glioblastoma multiforme

Question 6

Epidermal Growth Factor/Receptor Inhibitors-

Answer 6

bind to different areas of the epidermal growth
factor receptor which then blocks its activity to activate Tyrosine Kinase.

Question 7

EPIDERMAL GROWTH FACTOR INHIBITORS

Answer 7

Osimertinib

Question 8

Tyrosine Kinase Inhibitors/Signal transduction inhibitors

Answer 8

are the most common targeted
therapies. They are a part of a protein that acts like a cell’s on and off switch. Tyrosine kinase
inhibitors block these enzymes from sending signals that cause a cancer cell to grow or
multiply.

Question 9

Multikinase Inhibitors-

Answer 9

chemicals that directly obstruct the activity of specific kinases in cancer cells as well as cancer cell vasculature.

Question 10

TYROSINE KINASE INHIBITORS/ MULTIKINASE INHIBITORS

Answer 10

Alectinib

Question 11

mTOR Kinase Inhibitors-

Answer 11

atypical serine/threonine protein kinase that helps regulate cell growth,
proliferation, and survival. Inhibitors of mTOR lead to G1 arrest and apoptosis.

Question 12

mTOR KINASE INHIBITORS

Answer 12

Temserolimus

Question 13

Proteasome Inhibitor

Answer 13

blocks the action of proteasomes by preventing it from eating up excess
proteins.

Question 14

PROTEASOME INHIBITORS

Answer 14

Bortezomib

Question 15

Monoclonal antibodies (MAbs)

Answer 15

also known as therapeutic antibodies, are proteins
produced in the lab that imitates the body’s natural immune system to fight off cancer.

Question 16

fight off cancer.
M

Answer 16

Cetuximab