ANTIMALARIALS, ANTHELMINTICS, AND PEPTIDES Reporter 13

Question 1

Malaria

Answer 1

most prevalent protozoan diseases.

Question 2

Malaria
Cause:
Carrier:

Answer 2

Cause:
-protozoan parasites Plasmodium
Carrier:
-Anopheles mosquitoes

Question 3

Malaria

4 types:

Answer 3

P. malariae
P. ovale
P. vivax- most common
P. falciparm- most severe

Question 4

Malaria

2 Phases:

Answer 4

a. Tissue Phase- invasion of body tissue
b. Erythrocytic phase - invasion of the red blood cells

Question 5

ANTIMALARIAL DRUGS

General Side Effects and Adverse reactions

Answer 5

GI upset,
cranial nerve VIII involvement (quinine
and chloroquine)
, renal impairment,
and cardiovascular effects (quinine).

Question 6

is a commonly prescribed drug for malaria.

Answer 6

Chloroquine

Question 7

is an antidysrhythmic drug

Answer 7

Quinidine

Question 7

was the only antimalarial drug available from 1820 until the early 1940s a

Answer 7

Quinine

Question 8

toxic to children and may cause death.

Answer 8

Chloroquine and hydroxychloroquine-

Question 8

are frequently used to treat an acute malarial attack.

Answer 8

Chloroquine and mefloquine

Question 8

are used
to treat chloroquine-resistant P. falciparum

Answer 8

Mefloquine HCl and the combination drug atovaquone/proguanil (Malarone)

Question 9

Chloroquine HCl

Answer 9

SE: Anorexia, nausea, diarrhea, visual impairment, insomnia, photosensitivity.
AE: ECG Changes, hypotension, psychosis, seizures
CI: psoriasis, hypersensitivity, renal disease

Question 10

Most common site for helminthiasis (worm infection):

Answer 10

intestine

Question 11

General Side Effects and Adverse reactions

anthelmintics

Answer 11

GI distress, such as: anorexia, nausea, vomiting and occasionally diarrhea and
stomach cramps

Question 12

Anthelmintic Drugs

Praziquantel

Answer 12

Treatment of beef, pork and fish tapeworms; blood flukes and liver, lung, and
intestinal flukes
Caution: Dizziness

Question 13

Anthelmintic Drugs

Pyrantel Pamoate

Answer 13

For giant roundworm, hookworm, and pinworm.

Question 14

Anthelmintic Drugs

Ivermectin

Answer 14

Broad-spectrum anthelmintic drug that causes
paralysis to the parasite and effective against various
mites.
SE: Dizziness, Nausea, Pruritus
AE: Ocular effects and Opacity, Tachycardia,
Increased liver enzymes (AST, ALT)
CI: Asthma

Question 15

Two groups of peptides (antibiotics):

Answer 15

-Polymyxins and Bacitracin

Question 16

I. Antimicrobial Peptides

Polymyxins

Answer 16

Bactericidal effect

Question 17

I. Antimicrobial Peptides

Bacitracin

Answer 17

Inhibits bacterial cell-wall synthesis and
damages the cell-wall membrane

Question 18

I. Antimicrobial Peptides

Metronidazole

Answer 18

Used to treat disorders in the GI.
Anti-amoebic agen