BIOLOGIC RESPONSE MODIFIERS Reporter 19

Question 1

Biologic Response Modifiers

Answer 1

(immunotherapies)
- used to enhance, direct, or restore the body’s immune system
● can kill cancer cells directly or indirectly.
● BRMs that target cancer cells directly - targeted therapy

Question 2

Interferons (IFNs)

Answer 2

family of proteins that occur naturally in the body and are produced in the laboratory.
● slow the growth of cancer cells or cause them to behave more like normal cells

Question 3

Interferons (IFNs)

Interferon
alpha-2b
(IFN-α-2b)

Answer 3

AIDS-related Kaposi sarcoma, malignant melanoma, HBV,HCV, HPV

Question 4

Interferons (IFNs)

Interferon Beta
(IFN-β)

Answer 4

: treatment of MS

Question 5

Interferons (IFNs)

Interferon gamma
(IFN-γ)

Answer 5

chronic granulomatous disease and osteopetrosis

Question 6

Colony Stimulating Factors

Answer 6

• proteins that stimulate or regulate the growth, maturation, and
  differentiation of bone marrow stem cells. CSFs promote the growth of these blood cells, which
  increases the opportunity to continue with chemotherapy.

Question 7

Colony Stimulating Factors

Erythropoietin
(EPO)

Answer 7

Stimulates the division and differentiations of committed RBS
progenitors in the bone marrow

Question 8

Colony Stimulating Factors

Erythropoietin-S
timulating
agents (ESAs)

Answer 8

● used when blood transfusions are not an option
● administered as an injection to stimulate RBC production in the bone marrow.

Question 9

Colony Stimulating Factors

Granulocyte
Colony–Stimulat
ing Factor
(Filgastrim)

Answer 9

Stimulates proliferation, differentiation, and functional activity of
neutrophils, causing a rapid rise in WBC
● reduce incidence of infection in patients

Question 10

Interleukin 2

Answer 10

group of signaling-molecule proteins produced by leukocytes (T lymphocytes)
● increase the growth and activity of other T cells and B cells, which affect the immune
response system.

Question 11

Interleukin 2 -

Aldesleukin

Answer 11

For metastatic renal cancer and metastatic melanoma