Flashcards in Cartilage Deck (49):
What are chondroblasts?
Which cell type forms cartilage?
What is the term for a chondroblast that has become trapped in the ECM?
Is cartilage innervated?
What are the three types of cartilage?
1. Hyaline2. Elastic3. Fibrocartilage
What is the main component of hyaline cartilage?
Fine collagen fibrils (Type II)
What is the main component of elastic cartilage?
Fine collagen fibrils (Type II) + elastic fibers
What is the main component of fibrocartilage?
Parallel collagen bundles (Type I)
What is the most abundant type of cartilage?
How does hyaline cartilage appear upon staining?
Glassy, whitish blue
What type of cartilage is used to maintain lumens?
What type of cartilage is used to coat articular surfaces of bones?
What type of cartilage is used at epiphyseal plates of growing bones?
What are the general locations / functions of hyaline cartilage?
1. Lumen maintenance (nose, larynx, trachea, bronchi)2. Articular surfaces of bones3. Epiphyseal growth plates of bones
What are chondrification centers?
Sites of of future cartilage production
Chondrification centers are found in what type of cell?
What is the perichondrium?
CT capsule that covers ONLY hyaline and elastic cartilage
Perichondrium is a CT capsule that covers what types of cartilage?
Hyaline and elastic
What are the layers of the perichondrium?
1. Outer fibrous2. Inner cellular
What are the functions of the fibrous perichondrium?
1. Protective2. Supportive
What is the function of the inner cellular perichondrium?
Cartilage growth and maintenance
What type of cells are contained within the inner cellular perichondrium?
What is the definition of appositional growth in cartilage?
Growth of cartilage on the surface of existing cartilage
When does interstitial cartilage growth occur?
1. Early stages of cartilage formation2. In articular cartilage (no perichondrium)3. Epiphyseal plates4. Deep within cartilage (inside of tissue)
Articular cartilage exhibits what kind of cartilage growth?
Early stages of cartilage formation exhibits what kind of cartilage growth?
Growth deep within cartilage (inside of tissue) involves what kind of cartilage growth?
Growth of cartilage at epiphyseal plates is what kind of cartilage growth?
When does appositional cartilage growth occur?
1. Most cartilages2. Throughout lifespan of cartilage3. At surface of existing cartilage
What type of cartilage growth occurs in most cartilages?
What kind of cartilage growth is present throughout the lifespan of cartilage?
Does hyaline cartilage display interstitial growth, appositional growth, or both?
Chondrogenic cells can differentiate into what cell types?
1. Chondroblasts2. Osteoprogenitor cells
Can chondrocytes revert back to chondroblasts?
What is the function of chondrocytes?
Monitor matrix composition and synthesize necessary molecules to maintain cartilage matrix
What is the most abundant collagen type in hyaline cartilage?
Hyaluronan molecules serve as attachment sites for what molecule?
What is the capsular (pericellular) matrix?
Intensely stained thin layer of matrix immediately around the lacuna in the hyaline matrix
What part of the hyaline cartilage matrix contains the highest concentration of sulfated proteoglycans, hyaluronan and glycoproteins?
Capsular (pericellular) matrix
What is the territorial matrix?
Lighter staining matrix that surrounds the isogenous group in the hyaline matrix
What is the interterritorial matrix?
Represents the majority of the hyaline matrix; fills space around territorial matrix
What is the water composition of cartilage matrix?
How do nutrients get to hyaline cartilage?
Diffusion through ECM from nearby tissues
What cell type constantly monitors the matrix composition of cartilage?
Where is elastic cartilage located?
1. Pinna of the ear2. Internal and external auditory tubes3. Epiglottis4. Larynx
Does elastic cartilage calcify with aging?
Does hyaline cartilage calcify with aging?
Does fibrocartilage have a perichondrium?