Cartilage Flashcards Preview

Year 1 Cell Biology > Cartilage > Flashcards

Flashcards in Cartilage Deck (49):
1

What are chondroblasts?

Cartilage-forming cells

2

Which cell type forms cartilage?

Chondroblasts

3

What is the term for a chondroblast that has become trapped in the ECM?

Chondrocyte

4

Is cartilage innervated?

No

5

What are the three types of cartilage?

1. Hyaline2. Elastic3. Fibrocartilage

6

What is the main component of hyaline cartilage?

Fine collagen fibrils (Type II)

7

What is the main component of elastic cartilage?

Fine collagen fibrils (Type II) + elastic fibers

8

What is the main component of fibrocartilage?

Parallel collagen bundles (Type I)

9

What is the most abundant type of cartilage?

Hyaline

10

How does hyaline cartilage appear upon staining?

Glassy, whitish blue

11

What type of cartilage is used to maintain lumens?

Hyaline

12

What type of cartilage is used to coat articular surfaces of bones?

Hyaline

13

What type of cartilage is used at epiphyseal plates of growing bones?

Hyaline

14

What are the general locations / functions of hyaline cartilage?

1. Lumen maintenance (nose, larynx, trachea, bronchi)2. Articular surfaces of bones3. Epiphyseal growth plates of bones

15

What are chondrification centers?

Sites of of future cartilage production

16

Chondrification centers are found in what type of cell?

Mesenchymal cell

17

What is the perichondrium?

CT capsule that covers ONLY hyaline and elastic cartilage

18

Perichondrium is a CT capsule that covers what types of cartilage?

Hyaline and elastic

19

What are the layers of the perichondrium?

1. Outer fibrous2. Inner cellular

20

What are the functions of the fibrous perichondrium?

1. Protective2. Supportive

21

What is the function of the inner cellular perichondrium?

Cartilage growth and maintenance

22

What type of cells are contained within the inner cellular perichondrium?

Chondrogenic cells

23

What is the definition of appositional growth in cartilage?

Growth of cartilage on the surface of existing cartilage

24

When does interstitial cartilage growth occur?

1. Early stages of cartilage formation2. In articular cartilage (no perichondrium)3. Epiphyseal plates4. Deep within cartilage (inside of tissue)

25

Articular cartilage exhibits what kind of cartilage growth?

Interstitial

26

Early stages of cartilage formation exhibits what kind of cartilage growth?

Interstitial

27

Growth deep within cartilage (inside of tissue) involves what kind of cartilage growth?

Interstitial

28

Growth of cartilage at epiphyseal plates is what kind of cartilage growth?

Interstitial

29

When does appositional cartilage growth occur?

1. Most cartilages2. Throughout lifespan of cartilage3. At surface of existing cartilage

30

What type of cartilage growth occurs in most cartilages?

Appositional growth

31

What kind of cartilage growth is present throughout the lifespan of cartilage?

Appositional

32

Does hyaline cartilage display interstitial growth, appositional growth, or both?

Both

33

Chondrogenic cells can differentiate into what cell types?

1. Chondroblasts2. Osteoprogenitor cells

34

Can chondrocytes revert back to chondroblasts?

Yes

35

What is the function of chondrocytes?

Monitor matrix composition and synthesize necessary molecules to maintain cartilage matrix

36

What is the most abundant collagen type in hyaline cartilage?

Type II

37

Hyaluronan molecules serve as attachment sites for what molecule?

Proteoglycan monomers

38

What is the capsular (pericellular) matrix?

Intensely stained thin layer of matrix immediately around the lacuna in the hyaline matrix

39

What part of the hyaline cartilage matrix contains the highest concentration of sulfated proteoglycans, hyaluronan and glycoproteins?

Capsular (pericellular) matrix

40

What is the territorial matrix?

Lighter staining matrix that surrounds the isogenous group in the hyaline matrix

41

What is the interterritorial matrix?

Represents the majority of the hyaline matrix; fills space around territorial matrix

42

What is the water composition of cartilage matrix?

60-80%

43

How do nutrients get to hyaline cartilage?

Diffusion through ECM from nearby tissues

44

What cell type constantly monitors the matrix composition of cartilage?

Chondrocytes

45

Where is elastic cartilage located?

1. Pinna of the ear2. Internal and external auditory tubes3. Epiglottis4. Larynx

46

Does elastic cartilage calcify with aging?

No

47

Does hyaline cartilage calcify with aging?

Yes

48

Does fibrocartilage have a perichondrium?

No

49

Where is fibrocartilage located?

1. Intervertebral discs2. Pubic symphysis3. Articular discs (e.g. TMJ)4. Menisci of knee5. Attached to bone (e.g. tendon-bone junction)