Connective tissue Flashcards Preview

Year 1 Cell Biology > Connective tissue > Flashcards

Flashcards in Connective tissue Deck (36):
1

What are the embryological derivations of connective tissue?

1. Mesoderm2. Ectoderm (neural crest)

2

Which CT cell possesses the cellular machinery for the synthesis and secretion of fibers and ground substance?

Fibroblast (active)

3

Do active fibroblasts typically divide?

No

4

Under which circumstances would an active fibroblast divide?

Wound healing (fibroplasia)

5

Which is another term for a quiescent fibroblast?

Fibrocyte

6

What is another term for a fibrocyte?

Quiescent fibroblast

7

What are some characteristics of a fibrocyte compared to a fibroblast?

1. Smaller2. Spindle-shaped3. Fewer processes4. Eosinophilic cytoplasm5. Elongated and heterochromatic nucleus6. Nucleoli not visible

8

What is a myofibroblast?

Cell that possesses characteristics of fibroblasts and smooth muscle cell

9

Where are myofibroblasts commonly found?

Sites of wound healing

10

What is a Dupuytren's contracture?

Ischemic damage to palmar aponeurosis, fibroblasts and myofibroblasts replace Type I collagen with Type III. Contracture at MP joints due to excess deposition of Type III collagen crosslinking with myofibroblasts

11

Which digits are most commonly affected in a Dupuytren's conracture?

4th and 5th digits

12

Unilocular adipocytes are associated with what type of adipose tissue?

White adipose tissue

13

Which type of adipocyte has a signet ring appearance?

Unilocular adipocytes

14

What hormone is secreted by adipocytes to decrease appetite?

Leptin

15

What is the function of leptin?

Appetite suppression

16

What type of cell secretes leptin?

Adipocyte

17

What is lipodystrophy?

Loss of body fat

18

What is the term for loss of body fat?

Lipodystrophy

19

Which type of adipocyte contains a single large droplet not bound by a membrane by ensheated by vimentin fibers?

Unilocular adipocyte

20

Are multilocular adipocytes smaller or larger than unilocular adipocytes?

Smaller

21

Multilocular adipocytes have an abundance of what type of organelle?

Mitochondria

22

Is the nucleus displaced in multilocular adipocytes?

No

23

Is a mast cell a fixed or migratory CT cell?

Fixed

24

From where are mast cells derived?

Bone marrow

25

Where are mast cells usually located?

CT proper, adjacent to blood vessels and subepithelial layers of respiratory and GI tracts

26

Are mast cells found in nervous tissue?

No

27

Is a macrophage a fixed or migratory CT cell?

Fixed

28

What are the cytological characteristics of a macrophage?

1. Oval nucleus2. Clumps of heterochromatin along nuclear envelope3. Typically indented4. Eccentrically positioned in cytoplasm

29

Which organelles are abundant in macrophages?

1. Golgi2. rER3. Lysosomes

30

What are two functions of macrophages?

1. Phagocytose cellular debris2. Antigen presentation (to lymphocytes)

31

From what cell lineage are plasma cells?

B cells

32

What are the cytological attributes of plasma cells?

1. Large, ovoid2. Eccentrically located nucleus3. Clock face nucleus (heterochromatin dispersed around it)4. Very basophilic (a lot of rER)5. Prominent negative Golgi at light level

33

Which cell type has a clockface nucleus?

Plasma cell

34

Are antibodies secreted in a constitutive or regulated way by plasma cells?

Constiutive

35

In the 'first wave' of leukocyte infiltration, what cell type is most abundant?

Neutrophils

36

In the 'second wave' of leukocyte infiltration, what cell type is most abundant?

Monocytes