GI system IV Flashcards Preview

Year 1 Cell Biology > GI system IV > Flashcards

Flashcards in GI system IV Deck (30):
1

What makes up the portal triad?

1. Portal vein2. Hepatic artery3. Bile duct

2

What makes up a classic hepatic lobule?

1. Hepatocytes2. Sinusoids3. Central vein

3

What is the periportal space?

Located between CT and adjacent hepatocytes; presumed to be of lymphoid origin

4

What are hepatic sinusoids?

1. Discontinuous endothelium with large fenestrations and discontinuous basal lamina2. Kupffer cells present3. Perisinusoidal space (of Disse)

5

What is contained in the perisinusoidal space of Disse?

1. Hepatic stellate cell - contractile and CT elaboration2. Microvilli of hepatocytes

6

What is the dual blood supply to the liver?

Portal vein (75%) and proper hepatic artery (25%)

7

What is the unique feature of the stellate cell?

Large lipid droplet

8

What are the components that define the hepatic acinus?

Diamond shaped area bound by:1. 2 central veins2. 2 portal spaces

9

Which acinus zone has regenerative capacty?

Zone 1

10

Which acinus zone is first to show fat accumulation?

Zone 3

11

Which acinus zone is more susceptible to damage?

Zone 3

12

Which acinus zone has more detoxification enzymes?

Zone 3

13

What happens to colloid osmotic pressure with severe liver injury?

Decreases

14

What happens to blood clotting time with severe liver injury?

Increases

15

What is Gilbert syndrome?

Bilirubin conjugation is reduced

16

What is Crigler-Najjar syndrome?

Bilirubin conjugation is reduced (type II) or absent (type I)

17

What is Dubin-Johnson syndrome?

Decreased secretion of conjugated bilirubin due to absence of mdr-2 canalicular transport protein

18

What is the role of the perisinusoidal cell (stellate cell) in cirrhosis?

Collagen elaboration, contractility, fibrosis

19

What are the elements of the biliary tract?

1. Bile canuliculi2. Canals of Hering3. Bile ducts4. Hepatic ducts

20

What are the features of the bile canaliculi?

1. Limited by plasma membranes of two hepatocytes2. Tight junctions

21

What are the features of the canals of Hering?

1. Lined by simple cuboidal cholangiocytes and hepatocytes2. Stem cell niche

22

What type of epithelium makes up the bile ducts?

Simpel cuboidal to columnar

23

What type of epithelium makes up the hepatic ducts?

Simple columnar

24

What are the three layers of the gall bladder wall?

1. Mucosa2. Muscularis3. CT layer

25

What facilitates spread of gall bladder cancer to the liver?

Absence of submucosa and serosa on hepatic surface of gall bladder

26

What do the pancreatic acinar cells secrete?

Enzymes

27

What do the pancreatic ductal cells secrete?

Water and bicarbonate

28

What arrangement is unique to the pancreas?

Centroacinar cells - nuclei project into centers of acini; form intra-acinar portion of intercalated duct

29

What are the two primary causes of acute pancreatitis?

Alcohol and gallstones

30

Where are pancreatic enzymes stored?

Acinar cells (inactive form)