Vascular biology I Flashcards Preview

Year 1 Cell Biology > Vascular biology I > Flashcards

Flashcards in Vascular biology I Deck (25):
1

What are the layers of the blood vessel?

1. Tunica intima2. Tunica media3. Tunica adventitia

2

What makes up the tunica intima?

1. Endothelium2. Basal lamina3. Subendothelial layer

3

What makes up the subendothelial layer?

1. Loose connective tissue2. Scattered fibroblasts and in some arteries, smooth muscle cells3. Internal elastic lamina

4

What makes up the internal elastic lamina?

Elastin

5

What is the purpose of the fenestrae in the internal elastic lamina?

Diffusion of substances

6

Which blood vessel layer is fenestrated?

Internal elastic lamina

7

What makes up the tunica media?

1. Concentric layers of smooth muscle cells2. Variable amounts of elastin, elastic fibers, reticular fibers, proteoglycans3. External elastic lamina (elastin)

8

What makes up the tunica adventitia?

1. Connective tissue2. Type I collagen3. Elastic fibers4. Fibroblasts

9

The vasa vasorum contributes to what inflammatory condition of blood vessels?

Atherosclerosis

10

In syphilis, what component of the blood vessel becomes inflamed?

Vasa vasorum

11

How does inflammation of the vasa vasorum contribute to the pathogenesis of syphilis?

Obliteration of vasa vasorum leads to focal necrosis and scarring of the tunica media and degeneration of elastic lamellae

12

What is the nervi vasorum?

Network of autonomic nerve fibers supplying the vessel

13

Where are the nerve endings found on a blood vessel?

In the tunica adventitia (usually do not penetrate media but sometimes can)

14

Are the nerve fibers of blood vessels sympathetic or parasympathetic?

Usually sympathetic

15

What type of junctional complex exists between endothelial cells and smooth muscle cells?

Gap junction

16

Weibel-Palade bodies are found in what type of cell?

Endothelial cell

17

What is contained in Weibel-Palade bodies?

1. von Willebrand factor2. Tissue plasminogen activator3. Interleukin 84. P-selectin

18

Do endothelial cells promote coagulation, inhibit coagulation, or both?

Both

19

What kind of forces contribute to segmental modeling of vessels?

Mechanical and metabolic

20

Do elastic lamellae increase with age?

Yes

21

What happens to vessels in Marfan syndrome?

Severe elastic medial fragmentation with GAG area

22

What happens to the intima with age?

Progressive intimal fibrosis (thickening) and alterations of elastic elements

23

Is there a true tunica media in capillaries?

No

24

Is there a tunica adventitia in capillaries?

No

25

What are characteristics of pericytes?

1. Mesenchymal cells2. Contractile3. Can transform into smooth muscle cells and fibroblasts, for example4. Contribute to scar formation in CNS and possibly other organs5. Relatable to tunica media in capillaries