Flashcards in DIT Breast pathology Deck (18):
Mastitis is caused by what and how do you treat?
Tx with dicloxacillin and continued breast feeding
NOT DANGEROUS to infant
What is fibroadenoma?
Most common breast tumor under 25.
Small firm mass with regular edges
Increases in size with estrogen
How do you recognize non-proliferative changes in breast tissue?
Ages 25-50 and fluctuate with hormone levels. Can be tender and multiple bilateral breast lesions
What is intraductal papilloma?
Small tumor inside lactiferous ducts under areola and makes a serous/blood discharge. (maybe straw colored)
tiny cancer risk
What is a phyllodes tumor?
large bulky tumor and leaf-like projection on histology
What is comedocarinoma?
Caseous necrosis in Ductal carcionma in situ
Think of comedones like acne, it is gross and purulent.
What is paget's of the breast?
Eczema like patches of the nipple. CHECK for ductal carcinoma in situ (confined to duct). PAGET Cells are large cells in epidermis with halo.
What are Signet ring cells?
Cells with nucleus pushed to the side. in lobular carcinoma in situ
Also saw it with Kruckenberg tumors!
What type of breast tumor is almost always P+ and E+?
Lobular carcionma in situ
Does LCIS progress to invasive cancer?
DCIS will break through eventually. Always take out DCIS
LCIS may not have to take out cells, b/c sporadic carcinoma is often reoccurring.
What is invasive ductal carcinoma?
Firm, rock hard mass. Duct like cells. Will feel like fibroadenoma EXCEPT these won't move b/c infiltrating into tissues around it.
Most common and worst!
What is invasive lobular carcinoma?
Inactivation of E-cadherin (makes it malignant)
ER+ and PR +
Will have signet ring cells again
What is medullary carcinoma?
fleshy cellular mass with lymphocytic infiltrate. Good prognosis
What is inflammatory carcinoma?
Invasion of dermal lymphatics causes visible inflammatory changes
Dimpling of breasts
Tamoxifen mechanism? risks?
Estrogen antagonist in breast tissue (LCIS)
Estrogen agonist in endometrial tissue (careful for endometrial tissue)
Raloxifene mechanism? risks?
Estrogen agonist in bone used for osteoporosis
Antagonist in breast
No risk of endometrial cancer
Inhibits aromatase so androgen is not made into estrogen
Used for postmenopausal women with breast cancer b/c decreases estrogen load and stim of cancer cells
More osteoporosis risk