DIT cancer drugs (only on things specific to the drugs) Flashcards Preview

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Flashcards in DIT cancer drugs (only on things specific to the drugs) Deck (40):
1

Methotrexate mechanism?

S phase specific antimetabolite

Just like trimethoprim. DHF analog so no THF recharged and available for dUMP to dTMP

2

What is leucovorin?

Folic acid, basically. Used for helping fix myelosuppression from methotrexate

won't save 5FU

3

5 Flurouracil mechanism?

Pyrimidine analogue.
activated to 5F-dUMP to covaenlty bind folic acid and no thymidylate synthase activity

no dTMP and no DNA

4

Basal cell skin cancer and actinic keratosis treated with what?

5-FU

5

What is uridine?

Rescue for 5FU when myelosuppression

6

What 6-mercaptopurine?

purine analog, obviously. inhibits purine synthesis

7

What is significance of 6 mercaptopurine metabolism?

xanthine oxidase. So more toxicity if patient is on allopurinol

8

What is 6-thioguanine?

works like 6 mercaptopurine except not metabolized by xanthine oxidase

can be given with allopurinol

9

What is cytarabine?

CyTarabine is a pyrimidine analogue (C and T). it inhibits DNA polymerase

(its like acyclovir or rifampin, but for human DNA!)

10

Mechanism of cyclophosphamide?

covalently cross link DNA so cell can't replicate

Guanine specifically

11

what cancer drug can cause hemorrhagic cystitis? It also causes increased risk of bladder cancer (TCC).

how do you prevent it?w

KNOW THIS

cyclophosphamide b/c acrolein is toxic metabolite

Prevent with mesna

12

What are the nitrosoureas? What is the mechanism?
What is important about them?

What is the mnemonic?

Put nitro in your mustang! (mustines)

Carmstine, lomustine, semustine, streptozocin

alkylating agent. Needs bioactivation. BUT CAN CROSS BBB.

cross links DNA

13

Toxicity of nitrosoureas?

Crosses BBB so CNS tox

14

What is the mechanism of busulfan?

side effect?

X links DNA (alkylating agent again)

Pulmonary fibrosis is side effect (and busulfan tan but whatever)

15

Mechanism of rubicins?

generate free radicals

also intercalate DNA and causes breaks!

16

Side effect of rubicins?

CArdiotoxic (dilated cardiomyopathy) and heart failure

heart muscle susceptible b/c low levels superoxide dismutase. Rubicins make oxidative radicals

17

What is dexrazoxane?

Iron chelating agent that prevents cardiotoxicity of the rubicins?

18

What is mechanism of dactinomycin?

Intercalates DNA

19

What anticancer drug is used in pediatric cancers a lot?

Mnemonic

Dactinomycin

Children ACT out! dACTinomycin

20

Bleomycin mechanism?

Free radical formation which causes DNA to break (BLeo BLasts DNA)

21

Side effect of bleomycin?

Pulmonary fibrosis (same as busulfan, easy to remember b/c start with B's)

Methotrexate can cause fibrosis too

22

What three anticancer drugs cause pulm fibrosis?

Busulfan, bleomycin and methotrexate

23

What is a adriamycin?

It is a poor named rubicin

24

The platinum containing anti caner drugs work how?

Cross linkDNA. they are the ___platins

25

What cancer drugs have genitourinary association?

What is the bonus toxicity?

Platins are for treating testicular, ovarian and bladder cancer

But nephrotoxic also ototoxic

26

What drugs are nephrotoxic and ototoxic? 4 categories

Vanco
__platins
aminoglycosides
loop diuretics

27

What does Etoposide and teniposide work on?

Etoposide and Teniposide inhibit topo 2 (which unwinds DNA upstream

28

Step 1 likes testicular cancer (thats fucked up). What is a common regimen for treatment? mnemonic

Eradicate Ball Cancer

Etoposide
Bleomycin (or Ifosfamide)
Cisplatin

29

Mechanism for ironotecan and topotecan?

Inhibit topo1.

Diarrhea

30

Vincristine and vinblastine work how?

side effect?

Block polymerization of microtubules

Neuro toxicity. vinBLASTINE blasts bone marrow

31

Paclitaxel and taxels mechanism?

Hyperstabalize (TAXing to keep them polymerized)

32

Drugs that stabilize microtubules? not all cancer drugs

Microtubules G C very poorly

Mebendazole
griseofulvan
colchicine
Vincristine/blastine
paclitaxel

KNOW!

33

Mechanism of hydroxyurea?

Inhibtis ribonucleotide reductase

34

Prednisone mechanism as anti cancer drug?

May trigger apoptosis

especially lymph stuff (makes sense since immunosuppressant)

35

Mnemnoic for side effect of prednisone?

BAM CUSHINGOID

Buffalo hump
amenorrhea
moon facies
crazy (psychosis)
ulcers
skin changes (acne)
htn (aldosterone agonism)
infection
necrosis of femoral head
glaucoma/cataracts
osteoporosis
immunosuppression
diabetes

36

Tamoxifen mechanism?

SERM
estrogen receptor affect
Antagonist in breast
Agonist in bone and partial agonist in endometrium

ER breast cancer
Can prevent breast cancer if BRCA

increased risk of endometrial carcinoma (b/c overstimulation), but it stimulates less than estrogen, so helps there too. weird

37

Rolixefene mechanism?

SERM
Estrogen antagonist in breast and endometrium

Agonist in bone.
USED FOR OSTEOPOROSIS

38

Mechanism of trastuzumab?

Toxicity?

Her2 tyrosinekinase receptor monoclonal antibody for it

The trastuzumab trashy whore hurt my heart. CARDIOTOXIC

39

Rituxumab mechanism?

anti CD20

can help with lymphoma, leukemia, RH arthritis..

40

Imatinib mechanism?

nib means inhibitor, not monoclonal antibody

It is for BCR-ABL tyrosine kinse in (and if philly chromosome is anywhere else)