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Flashcards in DIT Lymphoma/Leukemia Deck (35):
1

What virus is able to cause Hodgkin lymphoma?

EBV

2

What is a big factor in prognosis of Hodgkin?

Lots of lymphocytes compared to Reed sternberg

3

Diffuse large B cell lymphoma is most common lymphoma in adults (happens in elderly)

What is the mutation

t 14;18 in 30%

14 is heavy chain and 18 is Bcl-2

4

What is most common lymphoma in kids?

Lymphoblastic

5

Translocation in follicular lymphoma? It is in adults with waxing an waining lymphadenopathy

t14;18 (in adults again. (this is the mutation seen in adults apparently))

14 is heavy chain and 18 is bcd-2

6

WhatNHL in kids is associated with EBV?

Burkitt lymhoma

(Starry sky).

Causes JAw lesion in africa

7

What is genes in burkitt lymphoma? mnemonic

t(8;14). Translocation of c-myc oncogene onto heavy chain

Write Burkitt so B looks like 8 and t's look like 14

(don't confuse with 14;18 in diffuse large cell and follicular lymphoma with is in adults and bcl-2)

8

What lymphoma has starry sky?

Burkitt (8urci14) to remember tranlocation and c-myc.

In kids

Only lymphocytes with interspersed macrophage which wate a ton of cancer cells

9

What is genes for mantle cell lymphoma?

t(11;14)

Think of man11e (for 11)

11 is for cyclin d to have more so more S phase of cell

manD1e (mantle) or man11e (mantle) cell lymphoma

older MALEs b/c MANtle

10

What is the NHL equivalent for CLL?

Small lymphocytic lymphoma

11

What is MALToma associated with?

SHH

Sjogren
Hashimoto
H pylori

12

Adult T cell lymphoma is aggressive. It is caused by what?

HTLV-1. Aggressive and associated with IV drug abuse.

13

What lymphoma is associated with celiac?

Intestinal (enteropathy-associated) T-cell

Sorry arie

14

Most comon lymphoma in adults?

In kids?

Adults: diffuse large B cell

Kids: lymphoblastic

15

Where do you find hodgkin lymphoma in the body?

In the population?

Bimodal age: so 20 or 65 usually

B SYMPTOMS!!!

contiguous spread

16

What type of cancer is PAS +?

Who gets it?

ALL (AML is PAS-)

Kids

Down syndrome (ALL fall Down)

17

Who gets AML?

Old people and down's syndrome or people with aplastic anemia

18

What has smudge cells?

CLL

19

What is philedalphia chromosome? What is the translocation?

Philadelphia CreaML cheese

CML

t 9;22

It is bcr-abl

20

CLL can cause what kind of hemolytic anemia?

both

21

What type of chronic leukemia is more likely to progress to acute?

CML is much more likely (80%)

CLL is only 10% progressing

22

What drug targets bcr-abl?

imatinib hits the tyrosine kinase.

23

What are the translocations?
9;22
8;14
11;14
14;18
15;17
8;21

9;22 philly CML bcr-abl
8;14 Burkitt: c-myc
11;14 Mantle cell: cyclin d1
14;18 diffuse large cell and follicular bcl-2
15;17 M3
8;21 s down syndrome b/c more likely to have the translocaiton with extra 21

24

What is pseudo-pelter-huet anomaly?

Sign of Myelodysplastic syndrome.


Neutrophils with bilobed nuclei (connected by thin filament of chromatin)

Looks like ted roosevelt glasses

25

What is myelodysplastic syndrome? what is risk?

Stem cell disorder of ineffective hematopoeisis. Risk of becoming AML

Pseudo pelger huet anomaly seen in smere (two nuclear masses looking like teddy roosevelt glasses)

26

What are the three chronic myeloproliferative disorders? What is the common mutation?

Polycythemia vera

Essential thromboytosis

Myelofirboris

JAK2: hematopoetic growth factor signaling

27

What is erythromelalgia?

Severe burning pain and reddish discoloration from episodic blood clots in vessels of extremities

Rare but classic symptom of polycythemia vera

28

Essential thrombocytosis is caused by what?

Symptoms?

Too much platelets. JAK2 mutation

Causes thrombosis or bleeding b/c platelets are not functional

29

What do cancerous cells look like in MM?

Plasma cells have clumps of chromatin looking like a clock and cytoplasm outside nucleus is cleared out.

Fried egg loock

30

4 common findings with multiple myeloma?

Cause of each?

Anemia: marrow filled with plasma cells

Renal insufficiency: immunoglobulin clogging up tubules

Back pain and Hypercalcemiacaused by local osteolytic factors that activate osteoclasts and inhibit osteoblasts

31

Findings in labs of blood and urine for MM?

Electrophoresis shows M spike

urine is Bence Jones proteins: Ig light chains in urine deced with electrophoresis

32

What are reouleaux formation?

RBCs are stacked in peripheral smear with MM

33

What is associated with Waldienstrom macroglobulinemia?

Similar to MM but some differences:

Hyper IgM (unlike MM which is IgA usually), and no bone lytic lesions like MM

34

What stains positive for TRAP? Mnemonic alert

Hairy cell leukemia.

TRAP the Hairy animal

35

What type of leukemia presents with bone pain?

ALL (MM also does, but I asked for leukemia)