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Flashcards in DIT DNA viruses Deck (32):
1

What can cause temporal lobe encephalitis?

HSV1

(most common cause of sporadic encephalitis in US)

2

Where does HSV 1 lay dormant?

Trigeminal ganglia (sensory neurons)

3

What causes keratoconjucntivitis and herpes labialis among other things?

HSV-1

4

Where does HSV-2 lay dormant?

Sacral nerve root ganglia

5

What type of virus is VZV? where is it latent?

varicella zoster is latent in DRG.

It is a herpes virus (HHV-3)

6

What do you see with positive Tzanck smear?

What tests positive?

HSV 1, 2, or VZV (makes sesnse, the ones that blister b/c you take the cells from the bottom of blisters)

Multinucleated giant cells

7

What has cowry bodies?

What are they?

HHV 1-3 (cows have herpes)

Intranuclear eosinophilic inclusions

8

What is sign and symptoms of EBV?

What happens if you mistreat it? IMPORTANT TO KNOW!

Looks like strep

Fever
Sore throat
Lymphadenopathy (post cervical nodes)
Exudative pharyngitis

Don't give amoxicillin, otherwise you GET A RASH. Maculopapular rash of turn and extremeties

9

What is Dx of EBV (aka HHV4)?

Monospot test: heterophile antibodies destroy HORSE and SHEEP RBCs

10

Mononucleosis but negative heterophile test? What is differential Dx?

CMV
ACUTE HIV DONT MISS
acute toxoplasmosis
viral hep
strept throat

11

EBV associated malignancies?

remember, latent in body for long time

Hodgkin lymphoma
Burkitt lymphoma
Nasopharyngeal carcinoma
Diffuse large cell lymphoma
Oral leukoplakia
Lymphoproliferative disorder

12

What are risks of CMV in AIDS?

Retinitis "sightomegalovirus"
Ulcer in GI tract
Esophagitis

13

What cells are infected by CMV?

Mononuclear cells. Cells. can be latently infected forever

14

What is roseola progression? What is the complication?

3-5 day fever (more than 102) followed by diffuse maculopapular rash (blotchy red everywhere)

Complication is possible febrile seizures.

Will be in kid before 2 years old

15

Dark flat nodular skin lesions in immunocompromised is what?

What can be affected?

Kaposi sarcoma. HHV-8.

Can affect GI and lungs (later can cause hemoptysis)

16

Acyclovir is for what diseases? Mechanism?

Side effects?

HSV, and VZV and weak EBV (no cmv)

Thymidine kinase of virus activates it to make a guanosine analog and interrupts transcription.

Maybe renal affects if poor hydration

17

Ganciclovir is for what disease?
Mechanism?

Toxicity?

5' monophosphate formed by CMV viral kinase and it is a guanosine analo

CMV IN IMMUNOCOMPROMISED

TOX: lower blood founds and higher creatinine (bone marrow suppression and renal tox)

18

Foscarnet is for what?
MEchanism?

Tox?

pyroFOSphate drug is FOScarnet

Inhibits DNA polymerase without activation of viral kinase

Renal tox (again) and anemia (makes sense)

Use: resistant HSV and CMV retinitis in immunocompromised who aren't responding

19

What are Downey cells?

T cells attacking EBV infection (they are the atypical T cells (not infected, just aggressive))

20

Lactulose mechanism?

Acidifies GI to trap NH4 and you won't asorb it when hyeprammonia

21

Homogentisic acid oxidase deficiency causes what?

alkaptonuria

22

Sickle cell patient has aplastic anemia. What is Dx?

Aplastic crisis in parvovirus (ssDNA)

23

Parvovirus presentation?

Kid with slapped cheeks

Adult: Rh arthritis like symptoms that resolves after a few weeks

24

What virus can cause hydrops fettles and miscarriage?

Parvovirus. (it is part of the Other in TORCH infections)

25

What papillomaviruses are bad?

What causes common warts?

Genome?

16 and 18 are bad

1 and 2 are common warts

Circular dsDNA

26

Which DNA virus have circular DNA?

O for circular in the Omavirus and hepadenavirus is partially stranded circular

papillOmavirus
polyOmavirus

27

Kid with URI followed by diarrhea. What is dx?

Adenovirus

28

What virus can cause aute hemorrhagic cystitis?

Adenovirus

29

Patient has flewsh colored dome lesions with central dimple. What is dx?

Molluscum contagiosum: VERY CONTAGIOUS. Leave them alone

Poxvirus. LARGE DNA VIRUS

30

Pox viruses are what?

Small pox
Cowpox (can be used as smallpox vaccine, duh)
Molluscum contagiosum

31

What is multifocal encephalitis in HIV? What other virus is of this family?

JC virus: progresive multifocal leukoencephalopathy in HIV

It is a polyOmavirus (circular DNA)

BK virus is Bad Kidney in transplant patients

32

What DNA virus has reverse transcriptase?

Hepadnavirus. It is HBV

partially double stranded circular

Enters nucleus, it is transcribed, then reverse transcribed into its DNA